ArticleImplementation science : IS2022
Stepped implementation-to-target: a study protocol of an adaptive trial to expand access to addiction medications.
Article in Implementation science : IS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343793 (Stagewise Implementation-To-Target- Medications for Addiction Treatment), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stagewise Implementation-To-Target- Medications for Addiction Treatment (SITT-MAT)
Who cites it
12 citing papers in PubMed.
- A pragmatic approach to estimating the cost to deliver and participate in implementation strategies.Implementation science : IS · 2025Trial
- The Behavioral Health Treatment Engagement and Retention Learning Collaborative to Improve Receipt and Continuity of Medication Treatment for Opioid Use Disorder.Substance use & addiction journal · 2026Article
- A mixed methods analysis of clinics' perspectives on community factors influencing access to medications for opioid use disorder.Addiction science & clinical practice · 2026Article
- Intelligent vulnerability assessment system for college students mental health based on few-sample reinforcement learning approach.Frontiers in psychiatry · 2026Article
- What scientific inferences can be made with randomized implementation rollout trials.Implementation science : IS · 2025Article
- Three trajectories of implementation of medications for opioid use disorder in primary care.Addiction science & clinical practice · 2025Article
- What is necessary for implementation science to actually improve the state of addiction treatment and research?Journal of substance use and addiction treatment · 2025Article
- Development and validation of a pragmatic measure of context at the organizational level: The Inventory of Factors Affecting Successful Implementation and Sustainment (IFASIS).Implementation science communications · 2025Article
- From glitter to gold: recommendations for effective dashboards from design through sustainment.Implementation science : IS · 2025Article
- Barriers and facilitators to use of buprenorphine in state-licensed specialty substance use treatment programs: A survey of program leadership.Journal of substance use and addiction treatment · 2024Article
- A data-driven approach to implementing the HPTN 094 complex intervention INTEGRA in local communities.Implementation science : IS · 2024Article
- Medication Approaches for Patients With Opioid Use Disorders: Differences Between Primary Care Clinics and Specialty Addiction Treatment Programs.Journal of addiction medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundIn response to the US opioid epidemic, significant national campaigns have been launched to expand access to `opioid use disorder (MOUD). While adoption has increased in general medical care settings, specialty addiction programs have lagged in both reach and adoption. Elevating the quality of implementation strategy, research requires more precise methods in tailoring strategies rather than a one-size-fits-all-approach, documenting participant engagement and fidelity to the delivery of the strategy, and conducting an economic analysis to inform decision making and policy. Research has yet to incorporate all three of these recommendations to address the challenges of implementing and sustaining MOUD in specialty addiction programs.
methodsThis project seeks to recruit 72 specialty addiction programs in partnership with the Washington State Health Care Authority and employs a measurement-based stepped implementation-to-target approach within an adaptive trial design. Programs will be exposed to a sequence of implementation strategies of increasing intensity and cost: (1) enhanced monitoring and feedback (EMF), (2) 2-day workshop, and then, if outcome targets are not achieved, randomization to either internal facilitation or external facilitation. The study has three aims: (1) evaluate the sequential impact of implementation strategies on target outcomes, (2) examine contextual moderators and mediators of outcomes in response to the strategies, and (3) document and model costs per implementation strategy. Target outcomes are organized by the RE-AIM framework and the Addiction Care Cascade. DISCUSSION: This implementation project includes elements of a sequential multiple assignment randomized trial (SMART) design and a criterion-based design. An innovative and efficient approach, participating programs only receive the implementation strategies they need to achieve target outcomes. Findings have the potential to inform implementation research and provide key decision-makers with evidence on how to address the opioid epidemic at a systems level.
trial registrationThis trial was registered at ClinicalTrials.gov (NCT05343793) on April 25, 2022.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.