ArticleBMC biology2022
Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera.
Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 51 citations in OpenAlex.
- Integrative screening of plant volatiles through transient receptor potential channel docking, olfactometry, and field validation in Bemisia tabaci.Pest management science · 2026Article
- Structural basis of sex pheromone detection in aphids.Cell research · 2026Article
- A Comprehensive Molecular and Evolutionary Characterization of Chemosensory-Related Genes inAnimals : an open access journal from MDPI · 2026Article
- Antennal transcriptome analysis and expression profiling of odorant binding proteins and odorant receptors in the teak defoliator, Hyblaea puera (Lepidoptera: Hyblaeidae).BMC genomics · 2026Article
- Synergistic attraction: Development and field evaluation of a multicomponent lure for Zeugodacus cucurbitae based on host-plant volatiles and gut bacterium-derived volatiles.Pest management science · 2026Article
- Function and Mechanism of ZcucOBP14 in Regulating Olfactory Recognition and Insecticide Susceptibility inInternational journal of molecular sciences · 2026Article
- Olfactory gene profiling in ticks: A scoping review with a functional perspective.Veterinary and animal science · 2026Review
- Harnessing CRISPR-Cas technology for insect pest control: current advances and future perspectives.Molecular biology reports · 2026Review
- Research Progress on Sex Pheromone Receptors in Insects.Insects · 2026Review
- IR25a-like Receptors are Required for Olfactory Detection of Plant Volatiles in the Carmine Spider Mite.Journal of chemical ecology · 2026Article
- Identification of candidate chemosensory receptors based on transcriptome analysis in the monophagous insect Protegira songi (Lepidoptera, Noctuidae).BMC genomics · 2026Article
- Exploring the Role of Pheromones and CRISPR/Cas9 in the Behavioral and Olfactory Mechanisms ofInsects · 2025Review
- Unveiling the developmental dynamics and functional role of Odorant Receptor Co-receptor (Orco) in Aedes albopictus: A novel mechanism for regulating odorant receptor expression.PLoS neglected tropical diseases · 2025Article
- Pheromone-Binding Proteins in Pest Control: From Molecular Insights to Real-World Applications.Journal of agricultural and food chemistry · 2025Review
- Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy.eLife · 2025Article
- Genetic and behavioral analyses suggest that larval and adult stages of Lucilia cuprina employ different sensory systems to detect rotten beef.Parasites & vectors · 2025Article
- HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.PLoS neglected tropical diseases · 2025Article
- CRISPR/Cas9-Based Genome Editing of Fall Armyworm (Biomolecules · 2024Review
- The larva and adult ofeLife · 2024Article
- Odorant receptor co-receptors affect expression of tuning receptors inFrontiers in cellular neuroscience · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOdorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or. Other types of olfactory receptor proteins, such as ionotropic receptors (IRs) and some gustatory receptors (GRs), are also involved in the olfactory system of insects. Orco as an obligatory subunit of ORs is highly conserved, providing an opportunity to systematically evaluate OR-dependent olfactory responses.
resultsHerein, we successfully established a homozygous mutant (Orco
conclusionsOur study indicates that OR-mediated olfaction is essential for pheromone communication, oviposition selection, and larval chemotaxis of H. armigera, suggesting a strategy in which mate searching and host-seeking behaviors of moth pests could be disrupted by inhibiting or silencing Orco expression.
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