Evidence map›Paper›PMID 36175848›Full record

ArticleBMC pediatrics2022

Remotely monitored transcranial direct current stimulation in pediatric cerebral palsy: open label trial protocol.

Emma A Simpson, Catarina Saiote, Ellen Sutter, Daniel H Lench, Chrysanthy Ikonomidou, Melissa A Villegas, Bernadette T Gillick

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05071586 (Remotely Monitored Transcranial Direct Current Stimulation in Children With Cerebral Palsy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05071586 nacompletednot on this map

Remotely Monitored Transcranial Direct Current Stimulation in Children With Cerebral Palsy

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2022 to 2023Enrolled10ConditionsCerebral Palsy (CP)ArmsSoterix 1x1 tDCS LTE Stimulator Device Model 1401
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The use of noninvasive brain stimulation techniques in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Emma A SimpsonWaisman Center, University of Wisconsin-Madison, 1500 Highland Avenue Room 491, Madison, Wisconsin, 53706, USA.
Catarina SaioteWaisman Center, University of Wisconsin-Madison, 1500 Highland Avenue Room 491, Madison, Wisconsin, 53706, USA.
Ellen SutterWaisman Center, University of Wisconsin-Madison, 1500 Highland Avenue Room 491, Madison, Wisconsin, 53706, USA.
Daniel H LenchDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
Chrysanthy IkonomidouDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Melissa A VillegasWaisman Center, University of Wisconsin-Madison, 1500 Highland Avenue Room 491, Madison, Wisconsin, 53706, USA.
Bernadette T GillickWaisman Center, University of Wisconsin-Madison, 1500 Highland Avenue Room 491, Madison, Wisconsin, 53706, USA. bgillick@wisc.edu.
University of Wisconsin–Madison · USMedical University of South Carolina · US

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
National Pediatric Rehabilitation Resource Center: Techniques DevelopmentP2CHD101912 · NICHD · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAMEY, SHARON LANDESMAN · 2020 to 2024
$5.0M
NICHD NIH HHS P2C HD101912NIGMS NIH HHS P20 GM109040
6 · The paper itself

Abstract

backgroundPediatric applications of non-invasive brain stimulation using transcranial direct current stimulation (tDCS) have demonstrated its safety with few adverse events reported. Remotely monitored tDCS, as an adjuvant intervention to rehabilitation, may improve quality of life for children with cerebral palsy (CP) through motor function improvements, reduced treatment costs, and increased access to tDCS therapies. Our group previously evaluated the feasibility of a remotely monitored mock tDCS setup in which families and children successfully demonstrated the ability to follow tDCS instructional guidance. METHODS AND

designHere, we designed a protocol to investigate the feasibility, safety, and tolerability of at-home active transcranial direct current stimulation in children with CP with synchronous supervision from laboratory investigators. Ten participants will be recruited to participate in the study for 5 consecutive days with the following sessions: tDCS setup practice on day 1, sham tDCS on day 2, and active tDCS on days 3-5. Sham stimulation will consist of an initial 30-second ramp up to 1.5 mA stimulation followed by a 30-second ramp down. Active stimulation will be delivered at 1.0 - 1.5 mA for 20 minutes and adjusted based on child tolerance. Feasibility will be evaluated via photographs of montage setup and the quality of stimulation delivery. Safety and tolerability will be assessed through an adverse events survey, the Box and Blocks Test (BBT) motor assessment, and a setup ease/comfort survey. DISCUSSION: We expect synchronous supervision of at-home teleneuromodulation to be tolerable and safe with increasing stimulation quality over repeated sessions when following a tDCS setup previously determined to be feasible. The findings will provide opportunity for larger clinical trials exploring efficacy and illuminate the potential of remotely monitored tDCS in combination with rehabilitation interventions as a means of pediatric neurorehabilitation. This will demonstrate the value of greater accessibility of non-invasive brain stimulation interventions and ultimately offer the potential to improve care and quality of life for children and families with CP.

trial registrationOctober 8, 2021( https://clinicaltrials.gov/ct2/show/NCT05071586 ).

Indexed as

Cerebral PalsyTranscranial Direct Current StimulationChildHumansMonitoring, PhysiologicQuality of LifeCerebral palsyChildrenMotor functionNon-invasive brain stimulationRemotely supervised tDCSTranscranial direct current stimulation (tDCS)

Identifiers

PMID36175848
PMCPMC9521558
OpenAlexW4297996594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.