Evidence map›Paper›PMID 36175470›Full record

ArticleScientific reports2022

Potential progression biomarkers of diabetic kidney disease determined using comprehensive machine learning analysis of non-targeted metabolomics.

Yosuke Hirakawa, Kentaro Yoshioka, Kensuke Kojima, Yasuho Yamashita, Takuma Shibahara, Takehiko Wada, Masaomi Nangaku, Reiko Inagi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  5. Observational
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  19. Kidney tea [Frontiers in pharmacology · 2024
    Article
  20. CKD Urine Metabolomics: Modern Concepts and Approaches.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yosuke HirakawaDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Kentaro YoshiokaKyowa Kirin Co., Ltd., Tokyo, Japan.
Kensuke KojimaKyowa Kirin Co., Ltd., Tokyo, Japan.
Yasuho YamashitaResearch and Development Group, Hitachi, Ltd., Tokyo, Japan.
Takuma ShibaharaResearch and Development Group, Hitachi, Ltd., Tokyo, Japan.
Takehiko WadaDivision of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. mnangaku@m.u-tokyo.ac.jp.
Reiko InagiDivision of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. inagi-r@m.u-tokyo.ac.jp.
The University of Tokyo · JPHitachi (Japan) · JPKyowa Kirin (Japan) · JPTokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic kidney disease is the main cause of end-stage renal disease worldwide. The prediction of the clinical course of patients with diabetic kidney disease remains difficult, despite the identification of potential biomarkers; therefore, novel biomarkers are needed to predict the progression of the disease. We conducted non-targeted metabolomics using plasma and urine of patients with diabetic kidney disease whose estimated glomerular filtration rate was between 30 and 60 mL/min/1.73 m

Indexed as

Diabetes MellitusDiabetic NephropathiesAlbuminsBiomarkersCreatinineHumansMachine LearningAlbuminsBiomarkersCreatinine

Identifiers

PMID36175470
PMCPMC9523033
OpenAlexW4298001098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.