Evidence map›Paper›PMID 36175417›Full record

ArticleScientific reports2022

Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by

Gregorio Naredo-Gonzalez, Rita Upreti, Maurits A Jansen, Scott Semple, Oliver B Sutcliffe, Ian Marshall, Brian R Walker, Ruth Andrew

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Mapping endocrine networks by stable isotope tracing.Current opinion in endocrine and metabolic research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Gregorio Naredo-GonzalezUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Rita UpretiUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Maurits A JansenUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Scott SempleUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Oliver B SutcliffeDepartment of Natural Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, UK.
Ian MarshallEdinburgh Imaging, Queen's Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Brian R Walker *University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK.
Ruth Andrew *University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK. ruth.andrew@ed.ac.uk.
University of Edinburgh · GBBritish Heart Foundation · GBManchester Metropolitan University · GBThe Queen's Medical Research Institute · GB

Funding

British Heart Foundation RG/11/4/28734Wellcome Trust
6 · The paper itself

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo pharmacodynamic biomarkers. Our goal was to monitor substrates and products of 11β-HSD1 non-invasively in liver via

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 1FluorineAnimalsDexamethasoneFluoridesGlucocorticoidsHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleRatsRats, Wistar11-beta-Hydroxysteroid Dehydrogenase Type 1DexamethasoneFluoridesFluorineGlucocorticoids

Identifiers

PMID36175417
PMCPMC9523021
OpenAlexW4298001258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.