Evidence map›Paper›PMID 36175271›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2023

Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions.

Prabha Siddarth, Matthew Abikenari, Adrienne Grzenda, Monica Cappelletti, Hanadi Oughli, Claire Liu, Michaela M Millillo, Helen Lavretsky

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. The Science of Tai Chi andJournal of integrative and complementary medicine · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Prabha SiddarthSemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Matthew AbikenariSemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Adrienne GrzendaSemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Monica CappellettiDepartment of Pathology and Laboratory Medicine, UCLA Immunogenetics Center (MC), Los Angeles, CA.
Hanadi OughliSemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Claire LiuSemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Michaela M MillilloSemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA.
Helen LavretskySemel Institute for Neuroscience and Human Behavior, UCLA (PS, MA, AG, HO, CL, MM, HL), Los Angeles, CA. Electronic address: hlavretsky@mednet.ucla.edu.
UCLA Medical Center · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Brain connectivity and response to Tai Chi in geriatric depressionR01AT008383 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2015 to 2019
$4.1M
Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
NCATS NIH HHS UL1 TR001881NCCIH NIH HHS K24 AT009198NCCIH NIH HHS R01 AT008383
6 · The paper itself

Abstract

backgroundUnderlying inflammation is associated with an increased risk of depression in older adults. In this study, we examined the role of inflammatory biomarkers in antidepressant response in depressed older adults undergoing adjunct Tai Chi Chih (TCC) or Health education interventions.

methodsOlder adults aged 60 years and above with a diagnosis of major depression were randomized to 12 weeks of TCC versus Health and Wellness Education (HEW) as an adjunct therapy to their stable antidepressant treatment regimen. A panel of 19 cytokine/chemokines was measured at baseline and 12 weeks. Five factors were derived using factor analysis. General linear models were estimated to examine the change in factor scores and the association of these changes on depression remission rates, controlling for age, sex, and body mass index.

resultsOf the 170 randomized participants (TCC: n = 85 and HEW: n = 85), 55 TCC and 58 HEW completed the 3-month assessment. The groups did not differ at baseline in any measure. At follow-up, neither the changes in cytokine/chemokines scores nor the depression remission rate differed significantly between TCC and HEW. However, remitters and non-remitters differed significantly in changes in a factor composed of growth-regulated oncogene protein-alpha (GRO-alpha), epidermal growth factor (EGF), and soluble CD40 ligand (sCD40L). GRO-alpha and EGF levels (in both groups) were significantly increased in remitters compared to non-remitters.

conclusionChanges in certain cytokines/chemokines may accompany improvement in depressive symptoms in older adults. Future studies will need to explore the role of these molecules in remission of late-life depression.

Indexed as

DepressionTai JiAgedAntidepressive AgentsBiomarkersCytokinesEpidermal Growth FactorHealth EducationHumansMiddle AgedAntidepressive AgentsBiomarkersCytokinesEpidermal Growth FactorcytokinesimmuneInflammationlate-life depressionmarkersremission of depression

Identifiers

PMID36175271
PMCPMC10865899
OpenAlexW4293331195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.