Evidence map›Paper›PMID 36175137›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

A Visual Interpretation Algorithm for Assessing Brain Tauopathy with

John P Seibyl, Jonathan M DuBois, Annie Racine, Jessica Collins, Qi Guo, Dustin Wooten, Eddie Stage, David Cheng, Roger N Gunn, Lilly Porat and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Impact of reducedEJNMMI physics · 2026
    Article
  5. Off-target binding ofAnnals of nuclear medicine · 2026
    Article
  6. Article
  7. Article
  8. Evaluation of a Sensitive Visual Read Algorithm for Assessing 3R/4R Tau PET Images.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  9. Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  10. Integrating visual assessments and quantification methods for tau PET staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  11. Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Article
  13. Visual reading for [European journal of nuclear medicine and molecular imaging · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Performance of a [Neurology · 2023
    Article
  19. Article
  20. Tau PET Visual Reads: Research and Clinical Applications and Future Directions.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

John P SeibylInstitute for Neurodegenerative Disorders, New Haven, Connecticut; jpseibyl@seibyl.com.
Jonathan M DuBoisBiogen, Cambridge, Massachusetts.
Annie RacineBiogen, Cambridge, Massachusetts.
Jessica CollinsBiogen, Cambridge, Massachusetts.
Qi GuoAbbVie, North Chicago, Illinois.
Dustin WootenBiogen, Cambridge, Massachusetts.
Eddie StageAbbVie, North Chicago, Illinois.
David ChengInvicro, New Haven, Connecticut.
Roger N GunnInvicro, New Haven, Connecticut.
Lilly PoratInvicro, New Haven, Connecticut.
Alex WhittingtonInvicro, New Haven, Connecticut.
Phillip H KuoUniversity of Arizona, Tucson, Arizona; and.
Masanori IchiseNational Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Robert ComleyAbbVie, North Chicago, Illinois.
Laurent MartarelloBiogen, Cambridge, Massachusetts.
Cristian SalinasBiogen, Cambridge, Massachusetts.
Biogen (United States) · USInvicro (United States) · USAbbVie (United States) · USInstitute for Neurodegenerative Disorders · USNational Institutes for Quantum and Radiological Science and Technology · JPUniversity of Arizona · US

Funding

Exploring Cognitive Aging Using Reference Ability Neural NetworksR01AG038465 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HABECK, CHRISTIAN GEORG, STERN, YAAKOV · 2011 to 2025
$17.0M
Anti-Viral therapy in Alzheimer's diseaseR01AG055422 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEVANAND, DAVANGERE P · 2017 to 2021
$10.6M
Longitudinal imaging of microglial activation in different clinical variants of Alzheimer's diseaseR01AG063888 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL, SCOTT A · 2020 to 2024
$4.8M
Biograph Horizon PET/CTS10OD025245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTIAN, BRADLEY T · 2018 to 2018
$1.3M
Imaging inflammation and tau in elders with different clinical and biomarker profiles of Alzheimer’s diseaseK23AG052633 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KREISL, WILLIAM CHARLES · 2016 to 2020
$789k
NIA NIH HHS K23 AG052633NIA NIH HHS R01 AG038465NIA NIH HHS R01 AG055422NIA NIH HHS R01 AG063888NIH HHS S10 OD025245
6 · The paper itself

Abstract

In vivo characterization of pathologic deposition of tau protein in the human brain by PET imaging is a promising tool in drug development trials of Alzheimer disease (AD). 6-(fluoro-

Indexed as

Alzheimer DiseaseBrainCross-Sectional StudiesHumansIsoquinolinesPositron-Emission Tomographytau ProteinsIsoquinolinesMK-6240tau ProteinsAlzheimer diseaseMK-6240neurologyPETtau proteinopathies

Identifiers

PMID36175137
PMCPMC10071795
OpenAlexW4297984045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.