Evidence map›Paper›PMID 36175126›Full record

ArticleJournal of medical ethics2024

How do US orthopaedic surgeons view placebo-controlled surgical trials? A pilot online survey study.

Michael H Bernstein, Maayan N Rosenfield, Charlotte Blease, Molly Magill, Richard M Terek, Julian Savulescu, Francesca L Beaudoin, Josiah D Rich, Karolina Wartolowska

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical ethics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Michael H BernsteinSchool of Public Health, Brown University, Center for Alcohol & Addiction Studies, Providence, Rhode Island, USA michael_bernstein@brown.edu.ORCID 0000-0001-7221-0697
Maayan N RosenfieldSchool of Public Health, Brown University, Center for Alcohol & Addiction Studies, Providence, Rhode Island, USA.
Charlotte BleaseGeneral Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Molly MagillSchool of Public Health, Brown University, Center for Alcohol & Addiction Studies, Providence, Rhode Island, USA.ORCID 0000-0001-5041-4664
Richard M TerekDepartment of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Julian SavulescuCentre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0003-1691-6403
Francesca L BeaudoinDepartment of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA.
Josiah D RichRhode Island Hospital, Providence, Rhode Island, USA.
Karolina WartolowskaNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0003-4049-2364
Brown University · USBeth Israel Deaconess Medical Center · USNational University of Singapore · SGUniversity of Oxford · GB

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI JOSIAH D RICH · 2018 to 2026
$23.4M
Harnessing Placebo Analgesia to Address the Opioid EpidemicK01DA048087 · NIDA · RHODE ISLAND HOSPITAL · PI BERNSTEIN, MICHAEL HARRISON · 2019 to 2023
$903k
NIDA NIH HHS K01 DA048087NIGMS NIH HHS P20 GM125507
6 · The paper itself

Abstract

Randomised placebo-controlled trials (RPCTs) are the gold standard for evaluating novel treatments. However, this design is rarely used in the context of orthopaedic interventions where participants are assigned to a real or placebo surgery. The present study examines attitudes towards RPCTs for orthopaedic surgery among 687 orthopaedic surgeons across the USA. When presented with a vignette describing an RPCT for orthopaedic surgery, 52.3% of participants viewed it as 'completely' or 'mostly' unethical. Participants were also asked to rank-order the value of five different types of evidence supporting the efficacy of a surgery, ranging from RPCT to an anecdotal report. Responses regarding RPCTs were polarised with 26.4% viewing it as the

Indexed as

Attitude of Health PersonnelOrthopedic SurgeonsRandomized Controlled Trials as TopicAdultFemaleHumansMaleMiddle AgedOrthopedic ProceduresOrthopedicsPilot ProjectsPlacebo EffectPlacebosSurveys and QuestionnairesUnited StatesPlacebospain management

Identifiers

PMID36175126
PMCPMC10050223
OpenAlexW4297996099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.