Evidence map›Paper›PMID 36175100›Full record

SynthesisBMJ open2022

Prevalence and risks of tuberculosis multimorbidity in low-income and middle-income countries: a meta-review.

Alexander Jarde, Eugenia Romano, Saima Afaq, Asma Elsony, Yan Lin, Rumana Huque, Helen Elsey, Kamran Siddiqi, B Stubbs, Najma Siddiqi

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Mechanisms ofBreathe (Sheffield, England) · 2026
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  14. Review
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  19. Tuberculosis and Increased Incidence of Cardiovascular Disease: Cohort Study Using United States and United Kingdom Health Records.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander JardeDepartment of Health Sciences, University of York, York, UK a.jarde@gmail.com.ORCID 0000-0002-2951-9741
Eugenia RomanoDepartment of Psychological Medicine, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.
Saima AfaqInstitute of Public Health and Social Sciences, Khyber Medical University, Peshawar, Pakistan.
Asma ElsonyPublic Health, Epi-Lab, Khartoum, Sudan.
Yan LinInternational Union Against Tuberculosis and Lung Disease, Beijing, China.
Rumana HuqueEconomics, University of Dhaka, Dhaka, Bangladesh.ORCID 0000-0002-7616-9596
Helen ElseyDepartment of Health Sciences, University of York, York, UK.ORCID 0000-0003-4724-0581
Kamran SiddiqiDepartment of Health Sciences, University of York, York, UK.ORCID 0000-0003-1529-7778
B StubbsDepartment of Psychological Medicine, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.
Najma SiddiqiDepartment of Health Sciences, University of York, York, UK.ORCID 0000-0003-1794-2152

Funding

Medical Research Council MC_PC_MR/T037806/1
6 · The paper itself

Abstract

objectivesCo-occurrence of tuberculosis (TB) with other chronic conditions (TB multimorbidity) increases complexity of management and adversely affects health outcomes. We aimed to map the prevalence of the co-occurrence of one or more chronic conditions in people with TB and associated health risks by systematically reviewing previously published systematic reviews.

designSystematic review of systematic reviews (meta-review).

settingLow-income and middle-income countries (LMICs). PAPERS: We searched in Medline, Embase, PsycINFO, Social Sciences Citation Index, Science Citation Index, Emerging Sources Citation Index and Conference Proceedings Citation Index, and the WHO Global Index Medicus from inception to 23 October 2020, contacted authors and reviewed reference lists. Pairs of independent reviewers screened titles, abstracts and full texts, extracted data and assessed the included reviews' quality (AMSTAR2). We included systematic reviews reporting data for people in LMICs with TB multimorbidity and synthesised them narratively. We excluded reviews focused on children or specific subgroups (eg, incarcerated people). PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence or risk of TB multimorbidity (primary); any measure of burden of disease (secondary).

resultsFrom the 7557 search results, 54 were included, representing >6 296 000 people with TB. We found that the most prevalent conditions in people with TB were depression (45.19%, 95% CI: 38.04% to 52.55%, 25 studies, 4903 participants, I

conclusionsWe identified several chronic conditions that co-occur in a significant proportion of people with TB. Although limited by varying quality and gaps in the literature, this first meta-review of TB multimorbidity highlights the magnitude of additional ill health burden due to chronic conditions on people with TB. PROSPERO REGISTRATION NUMBER: CRD42020209012.

Indexed as

MultimorbidityTuberculosisChildDeveloping CountriesHumansPrevalenceSystematic Reviews as Topicepidemiologypublic healthtuberculosis

Identifiers

PMID36175100
PMCPMC9528681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.