ArticleJACC. Heart failure2022
Periodontal Status, C-Reactive Protein, NT-proBNP, and Incident Heart Failure: The ARIC Study.
Article in JACC. Heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.International journal of molecular sciences · 2026Pooled it
- Periodontitis and the Risk of Heart Failure:a Meta-analysis and Mendelian Randomisation Study.Oral health & preventive dentistry · 2025Pooled it
- Periodontal Disease and Heart Failure: Current Evidence and Perspectives.Current cardiology reports · 2026Review
- Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).Molecular medicine reports · 2026Review
- Dysbiosis of oral bacteriome and mycobiome associated with the severity of heart failure.BMC oral health · 2026Article
- Collective exerkines mediate physical activity mitigating new-onset heart failure risk in older adults with prediabetes or diabetes: a community-based longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Diet Quality and Advanced Periodontitis in Relation to Serum CRP Levels: An 11-Year Follow-Up Study.Food science & nutrition · 2026Article
- Strong Heart, Strong Smile: Tooth Loss and Incidence of CVD in American Indian Populations.Community dentistry and oral epidemiology · 2026Article
- Periodontal Disease and Risk of Heart Failure: A Systematic Review and Meta-Analysis.International journal of dentistry · 2026Article
- Impact of Tooth Loss on Heart Failure After Myocardial Infarction: A Cross-Sectional Study Bridging Oral and Cardiovascular Health.Dentistry journal · 2025Article
- Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Age modulates the link between stress-related neural activity and mortality.Nature communications · 2025Article
- Association between periodontitis and rupture of saccular intracranial aneurysms: a multicenter cross-sectional study.Neurosurgical review · 2025Article
- Periodontitis Accelerates Progression of Heart Failure With Preserved Ejection Fraction in Mice.JACC. Basic to translational science · 2025Article
- The relation between C-reactive protein (CRP) and risk of incident heart failure in patients with cardiovascular disease: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Infection-Related Hospitalization and Incident Heart Failure in MarketScan: A Case-Crossover Study.Journal of the American Heart Association · 2025Article
- Infection-Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Article
- Noninvasive Oral Hyperspectral Imaging-Driven Digital Diagnosis of Heart Failure With Preserved Ejection Fraction: Model Development and Validation Study.Journal of medical Internet research · 2025Article
- Decline in oral function contributes to decreased activities of daily living at discharge in elderly patients with heart failure.PloS one · 2025Article
- The tongue coating microbiome is perturbed in atrial fibrillation and partly normalized after catheter ablation.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPeriodontal disease (PD), resulting from inflammatory host response to dysbiotic subgingival microbiota, has been linked to cardiovascular disease; however, its relationship to heart failure (HF) and its subtypes (heart failure with reduced ejection fraction [HFrEF] and heart failure with preserved ejection fraction [HFpEF]) is unexplored.
objectivesThe authors hypothesize that the presence of PD is associated with increased risk of incident HF, HFpEF, and HFrEF.
methodsA total of 6,707 participants (mean age 63 ± 6 years) of the ARIC (Atherosclerosis Risk In Communities) study with full-mouth periodontal examination at visit 4 (1996-1998) and longitudinal follow-up for any incident HF (visit 4 to 2018), or incident HFpEF and HFrEF (2005-2018) were included. Periodontal status was classified as follows: healthy, PD (as per Periodontal Profile Classification [PPC]), or edentulous. Multivariable-adjusted Cox proportional hazards models were used to calculate HRs and 95% CIs for the association between PPC levels and incident HF, HFpEF, or HFrEF. Additionally, biomarkers of inflammation (C-reactive protein [CRP]) and congestion (N-terminal brain natriuretic peptide [NT-proBNP]) were assessed.
resultsIn total, 1,178 incident HF cases occurred (350 HFpEF, 319 HFrEF, and 509 HF of unknown type) over a median of 13 years. Of these cases, 59% had PD, whereas 18% were edentulous. PD was associated with an increased risk for HFpEF (HR: 1.35 [95% CI: 0.98-1.86]) and significantly increased risk for HFrEF (HR: 1.69 [95% CI: 1.18-2.43]), as was edentulism: HFpEF (HR: 2.00 [95% CI: 1.37-2.93]), HFrEF (HR: 2.19 [95% CI: 1.43-3.36]). Edentulism was associated with unfavorable change in CRP and NT-proBNP, whereas PD was associated only with CRP.
conclusionsPeriodontal status was associated with incident HF, HFpEF, and HFrEF, as well as unfavorable changes in CRP and NT-proBNP.
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