Evidence map›Paper›PMID 36175033›Full record

ArticleGenes & development2022

Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage.

Cameron W Berry, Gonzalo H Olivares, Lorenzo Gallicchio, Gokul Ramaswami, Alvaro Glavic, Patricio Olguín, Jin Billy Li, Margaret T Fuller

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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  9. Deficiency ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Cameron W Berry *Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.ORCID 0000-0003-1096-2804
Gonzalo H Olivares *Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Lorenzo GallicchioDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.ORCID 0000-0002-5040-0139
Gokul RamaswamiDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Alvaro GlavicCenter for Genome Regulation (CRG), Universidad de Chile, Santiago 7810000, Chile.
Patricio OlguínDrosophila Ring in Developmental Adaptations to Nutritional Stress (DRiDANS), Universidad de Chile, Santiago 7810000, Chile.
Jin Billy LiDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Margaret T FullerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.ORCID 0000-0002-3804-4987
Stanford University · USCentre for Genomic Regulation · ESInstituto de Neurociencia Biomédica · CLUniversidad Mayor · CL

Funding

Regulation of proliferation and differentiation in the male germ line adult stem cell lineageR35GM136433 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER · 2020 to 2026
$5.9M
Postgraduate Training Program in Epithelial BiologyT32AR007422 · NIAMS · STANFORD UNIVERSITY · PI PAUL KHAVARI · 1986 to 2026
$5.0M
Developmentally programmed translational control of specialized cell cycles in male meiosisR01GM124054 · NIGMS · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2018 to 2019
$628k
Alternative polydenylation and the regulation of male germ cell differentiationR21HD079970 · NICHD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2014 to 2015
$436k
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
NIAMS NIH HHS T32 AR007422NICHD NIH HHS R21 HD079970NIGMS NIH HHS R01 GM124054NIGMS NIH HHS R35 GM136433NIH HHS S10 OD010580
6 · The paper itself

Abstract

Alternative polyadenylation (APA) generates transcript isoforms that differ in the position of the 3' cleavage site, resulting in the production of mRNA isoforms with different length 3' UTRs. Although widespread, the role of APA in the biology of cells, tissues, and organisms has been controversial. We identified >500

Indexed as

Adult Stem CellsRNA Isoforms3' Untranslated RegionsAnimalsMalePolyadenylationProtein IsoformsRNA, Messenger3' Untranslated RegionsProtein IsoformsRNA IsoformsRNA, Messengeralternative polyadenylationmRNA isoformsspermatogenesistranslational control

Identifiers

PMID36175033
PMCPMC9575692
OpenAlexW4297980945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.