Evidence map›Paper›PMID 36174996›Full record

ArticleAllergy, asthma & immunology research2022

Atopic Dermatitis With Coexisting Food Allergy in Early Life Is Associated With Childhood Asthma.

Sungsu Jung, So-Yeon Lee, Jisun Yoon, Hyun-Ju Cho, Min Jee Park, Kun Baek Song, Eom Ji Choi, Eun Young Paek, Song-I Yang, Eun Lee and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Sungsu JungDepartment of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea.ORCID https://orcid.org/0000-0002-0559-4982
So-Yeon LeeDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2499-0702
Jisun YoonDepartment of Pediatrics, College of Medicine, Chung-Ang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-4904-9118
Hyun-Ju ChoDepartment of Pediatrics, International St. Mary's Hospital, Catholic Kwandong University, Incheon, Korea.ORCID https://orcid.org/0000-0003-4282-4000
Min Jee ParkDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0891-1311
Kun Baek SongDepartment of Pediatrics, Soonchunhyang University Cheonan Hospital, School of Medicine, Soonchunhyang University, Cheonan, Korea.ORCID https://orcid.org/0000-0001-6981-6292
Eom Ji ChoiDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1122-1592
Eun Young PaekDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3523-7801
Song-I YangDepartment of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.ORCID https://orcid.org/0000-0002-9648-4585
Eun LeeDepartment of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.ORCID https://orcid.org/0000-0002-0145-7067
Soo-Jong HongDepartment of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr.ORCID https://orcid.org/0000-0003-1409-2113
PSKC Study Group
Ulsan College · KRCatholic Kwandong University International St. Mary's Hospital · KRChonnam National University Hospital · KRChung-Ang University · KRHallym University Sacred Heart Hospital · KRPusan National University Yangsan Hospital · KRSoonchunhyang University · KR

Funding

Korea Centers for Disease Control and Prevention 2015-ER6601-00National Research Foundation of Korea NRF-2020R1A2C2012822National Research Foundation of Korea NRF-2021R1A2C2095664
6 · The paper itself

Abstract

purposeAtopic dermatitis (AD) and food allergy (FA) are associated with respiratory comorbidities, in the concept of 'atopic march.' However, children with AD and a coexisting FA have various disease courses, and the mechanism of atopic march remains unclear. In this study, we investigated whether the phenotype of AD with coexisting FA in early life affected asthma or allergic rhinitis (AR) in school children.

methodsA total of 1,579 children from the Panel Study on Korean Children (PSKC) cohort were followed-up in 2013. The participants diagnosed with AD in this cohort were classified by the age of AD onset and persistence as well as FA history. We compared the presence of comorbidities-asthma and rhinitis-among different AD phenotypes.

resultsAsthma and AR with current symptoms within 12 months at age 6-8 years were associated with early-onset persistent AD phenotype, regardless of coexisting FA. AD with FA conferred a higher risk of recent wheezing at 8 years of age than AD without FA (adjusted odds ratio, 8.09; 95% confidence interval, 2.54-25.76). Children with early-onset persistent AD with FA manifested a distinctive trajectory with a higher prevalence of wheezing and AR at age 5-8 years than those without AD.

conclusionsAD with FA in early life is strongly associated with asthma and AR in school children, and the early-onset persistent AD with FA had a strong additive effect on the risk of asthma at school age. Classifying AD phenotypes regarding FA in early life will help predict and prevent asthma and AR in school children.

Indexed as

asthmaAtopic dermatitisatopic marchchildrenfood allergyphenotype

Identifiers

PMID36174996
PMCPMC9523419
OpenAlexW4298087265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.