Evidence map›Paper›PMID 36174982›Full record

ArticleJournal of veterinary science2022

Antibacterial activity of florfenicol composite nanogels against

Jinhuan Liu, Mujie Ju, Yifei Wu, Nannan Leng, Samah Attia Algharib, Wanhe Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jinhuan LiuEngineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang 843300, China.ORCID https://orcid.org/0000-0003-4978-2229
Mujie JuEngineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang 843300, China.ORCID https://orcid.org/0000-0003-0826-509X
Yifei WuEngineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang 843300, China.ORCID https://orcid.org/0000-0002-8016-7702
Nannan LengEngineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang 843300, China.ORCID https://orcid.org/0000-0002-2588-3490
Samah Attia AlgharibDepartment of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, QG, Egypt.ORCID https://orcid.org/0000-0002-3336-2855
Wanhe LuoEngineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang 843300, China.ORCID https://orcid.org/0000-0002-5170-1670

Funding

Program for Young and Middle-aged Technology Innovation Leading Talents 2019CB029Tarim University TDZKSS202144
6 · The paper itself

Abstract

backgroundFlorfenicol might be ineffective for treating

objectivesIn this study, florfenicol-loaded chitosan (CS)-sodium tripolyphosphate (TPP) composite nanogels were prepared to allow targeted delivery to SCV infected sites.

methodsThe formulation screening, the characteristics,

resultsThe optimized formulation was obtained when the CS and TPP were 10 and 5 mg/mL, respectively. The encapsulation efficiency, loading capacity, size, polydispersity index, and zeta potential of the optimized florfenicol composite nanogels were 87.3% ± 2.7%, 5.8% ± 1.4%, 280.3 ± 1.5 nm, 0.15 ± 0.03, and 36.3 ± 1.4 mv, respectively. Optical and scanning electron microscopy showed that spherical particles with a relatively uniform distribution and drugs might be incorporated in cross-linked polymeric networks. The

conclusionsFlorfenicol composite nanogels might improve the treatment of SCV infections.

Indexed as

ChitosanMastitisStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsDelayed-Action PreparationsFemaleNanogelsStaphylococcus aureusThiamphenicolAnti-Bacterial AgentsChitosanDelayed-Action PreparationsflorfenicolNanogelsThiamphenicolantibacterial activitybiosafetyFlorfenicolStaphylococcus aureus small colony variantstherapeutic efficacy

Identifiers

PMID36174982
PMCPMC9523337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.