Evidence map›Paper›PMID 36174980›Full record

ArticleJournal of veterinary science2022

Dexamethasone enhances glucose uptake by SGLT1 and GLUT1 and boosts ATP generation through the PPP-TCA cycle in bovine neutrophils.

Xinbo Wang, Mingyu Tang, Yuming Zhang, Yansong Li, Jingdong Mao, Qinghua Deng, Shusen Li, Zhenwei Jia, Liyin Du

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xinbo Wang *College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0001-9842-1855
Mingyu Tang *College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0003-4423-3060
Yuming Zhang *College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0003-4523-6618
Yansong Li *College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0003-4041-9140
Jingdong Mao *College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0003-4283-9253
Qinghua DengCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0002-3659-0984
Shusen LiCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0002-6315-247X
Zhenwei JiaCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0002-3855-8603
Liyin DuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China.ORCID https://orcid.org/0000-0002-1513-0479
Minzu University of China · CNInner Mongolia University for Nationalities · CN

Funding

National Natural Science Foundation of China 31260626National Natural Science Foundation of China 31760752Natural Science Foundation of Inner Mongolia 2018LH03009Natural Science Foundation of Inner Mongolia 2019LH03020Young Scientific and Technological Talents in Inner Mongolia NJYT-20-B30
6 · The paper itself

Abstract

backgroundClinical dexamethasone (DEX) treatment or stress in bovines results in extensive physiological changes with prominent hyperglycemia and neutrophils dysfunction.

objectivesTo elucidate the effects of DEX treatment in vivo on cellular energy status and the underlying mechanism in circulating neutrophils.

methodsWe selected eight-month-old male bovines and injected DEX for 3 consecutive days (1 time/d). The levels of glucose, total protein (TP), total cholesterol (TC), and the proinflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in blood were examined, and we then detected glycogen and adenosine triphosphate (ATP) content, phosphofructosekinase-1 (PFK1) and glucose-6-phosphate dehydrogenase (G6PDH) activity, glucose transporter (GLUT)1, GLUT4, sodium/glucose cotransporter (SGLT)1 and citrate synthase (CS) protein expression and autophagy levels in circulating neutrophils.

resultsDEX injection markedly increased blood glucose, TP and TC levels, the Ca

conclusionsDEX induced neutrophils glucose uptake by enhancing SGLT1 and GLUT1 expression and the transformation of energy metabolism from glycolysis to pentose phosphate pathway (PPP)-tricarboxylic acid (TCA) cycle. This finding gives us a new perspective on deeper understanding of clinical anti-inflammatory effects of DEX on bovine.

Indexed as

Adenosine TriphosphateNeutrophilsAnimalsAnti-Inflammatory AgentsBlood GlucoseCattleCholesterolCitrate (si)-SynthaseDexamethasoneGlucosephosphate DehydrogenaseGlucose Transporter Type 1GlycogenInterleukin-6MaleSodiumTricarboxylic AcidsAdenosine TriphosphateAnti-Inflammatory AgentsBlood GlucoseCholesterolCitrate (si)-SynthaseDexamethasoneGlucosephosphate DehydrogenaseGlucose Transporter Type 1GlycogenInterleukin-6SodiumTricarboxylic AcidsTumor Necrosis Factor-alphaAdenosine TriphosphateBovineDexamethasoneNeutrophilsTricarboxylic Acid Cycle

Identifiers

PMID36174980
PMCPMC9523333
OpenAlexW4294700086

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.