Evidence map›Paper›PMID 36174872›Full record

ArticleInternational journal of biological macromolecules2022

Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.

Sk Sarif Hassan, Vaishnavi Kodakandla, Elrashdy M Redwan, Kenneth Lundstrom, Pabitra Pal Choudhury, Ángel Serrano-Aroca, Gajendra Kumar Azad, Alaa A A Aljabali, Giorgio Palu, Tarek Mohamed Abd El-Aziz and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 19 institutions in 12 countries.

Sk Sarif HassanDepartment of Mathematics, Pingla Thana Mahavidyalaya, Maligram, Paschim Medinipur, 721140, West Bengal, India. Electronic address: sksarifhassan@pinglacollege.ac.in.
Vaishnavi KodakandlaDepartment of Life sciences, Sophia College For Women, University of Mumbai, Bhulabhai Desai Road, Mumbai 400026, India.
Elrashdy M RedwanBiological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, New Borg EL-Arab 21934, Alexandria, Egypt. Electronic address: lradwan@kau.edu.sa.
Kenneth LundstromPanTherapeutics, Rte de Lavaux 49, CH1095 Lutry, Switzerland. Electronic address: lundstromkenneth@gmail.com.
Pabitra Pal ChoudhuryIndian Statistical Institute, Applied Statistics Unit, 203 B T Road, Kolkata 700108, India.
Ángel Serrano-ArocaBiomaterials and Bioengineering Lab, Centro de Investigacion Traslacional San Alberto Magno, Universidad Cat'olica de Valencia San Vicente Martir, c/Guillem de Castro, 94, 46001 Valencia, Valencia, Spain. Electronic address: angel.serrano@ucv.es.
Gajendra Kumar AzadDepartment of Zoology, Patna University, Patna, Bihar, India. Electronic address: gkazad@patnauniversity.ac.in.
Alaa A A AljabaliDepartment of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Faculty of Pharmacy, Irbid 566, Jordan. Electronic address: alaaj@yu.edu.jo.
Giorgio PaluDepartment of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy. Electronic address: giorgio.palu@unipd.it.
Tarek Mohamed Abd El-AzizZoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. Electronic address: mohamedt1@uthscsa.edu.
Debmalya BarhCentre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India; Departamento de Geńetica, Ecologia e Evolucao, Instituto de Cíencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Bruce D UhalDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Parise AdadiDepartment of Food Science, University of Otago, Dunedin 9054, New Zealand.
Kazuo TakayamaCenter for iPS Cell Research and Application, Kyoto University, Kyoto 6068507, Japan. Electronic address: kazuo.takayama@cira.kyoto-u.ac.jp.
Nicolas G BazanNeuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA 70112, USA. Electronic address: nbazan@lsuhsc.edu.
Murtaza TambuwalaSchool of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK. Electronic address: m.tambuwala@ulster.ac.uk.
Samendra P SherchanLincoln Medical School, University of Lincoln, Brayford Pool Campus, Lincoln LN6 7TS, UK. Electronic address: sshercha@tulane.edu.
Amos LalDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Gaurav ChauhanSchool of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, 64849 Monterrey, Nuevo León, Mexico. Electronic address: gchauhan@tec.mx.
Wagner Baetas-da-CruzTranslational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Vladimir N UverskyDepartment of Molecular Medicineand USF Health Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny 141700, Russia. Electronic address: vuversky@usf.edu.
City of Scientific Research and Technological Applications · EGIndian Statistical Institute · INInstitute of Bioinformatics and Applied Biotechnology · INKyoto University · JPLouisiana State University Health Sciences Center New Orleans · USMayo Clinic in Arizona · USMichigan State University · USPanthera Corporation · USPatna University · INTecnológico de Monterrey · MXThe University of Texas Health Science Center at San Antonio · USUniversidade Federal do Rio de Janeiro · BRUniversity of Lincoln · GBUniversity of Mumbai · INUniversity of Otago · NZUniversity of Padua · ITUniversity of Ulster · GBValencia Catholic University Saint Vincent Martyr · ESYarmouk University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several hypotheses have been presented on the origin of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from its identification as the agent causing the current coronavirus disease 19 (COVID-19) pandemic. So far, no solid evidence has been found to support any hypothesis on the origin of this virus, and the issue continue to resurface over and over again. Here we have unfolded a pattern of distribution of several mutations in the SARS-CoV-2 proteins in 24 geo-locations across different continents. The results showed an evenly uneven distribution of the unique protein variants, distinct mutations, unique frequency of common conserved residues, and mutational residues across these 24 geo-locations. Furthermore, ample mutations were identified in the evolutionarily conserved invariant regions in the SARS-CoV-2 proteins across almost all geo-locations studied. This pattern of mutations potentially breaches the law of evolutionary conserved functional units of the beta-coronavirus genus. These mutations may lead to several novel SARS-CoV-2 variants with a high degree of transmissibility and virulence. A thorough investigation on the origin and characteristics of SARS-CoV-2 needs to be conducted in the interest of science and for the preparation of meeting the challenges of potential future pandemics.

Indexed as

COVID-19SARS-CoV-2HumansMutationPandemicsSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Evenly-unevenFurin cleavage site (FCS)Invariant regionsMutationsSARS-CoV-2

Identifiers

PMID36174872
PMCPMC9511875
OpenAlexW4297142802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.