Evidence map›Paper›PMID 36174771›Full record

ArticleImmunology letters2022

SARS-CoV-2-specicific humoral immunity in convalescent patients with mild COVID-19 is supported by CD4

Marcus Odendahl, Iris Endler, Beate Haubold, Roman N Rodionov, Stefan R Bornstein, Torsten Tonn

Open access · greenAbstract read
In one paragraph

Article in Immunology letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Marcus OdendahlExperimental Transfusion Medicine, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany. Electronic address: M.Odendahl@blutspende.de.
Iris EndlerExperimental Transfusion Medicine, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.
Beate HauboldInstitute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany.
Roman N RodionovDepartment of Medicine III, University Hospital Carl-Gustav, Dresden, Germany.
Stefan R BornsteinDepartment of Medicine III, University Hospital Carl-Gustav, Dresden, Germany; Department of Diabetes, School of Life Course Science and Medicine, King's College London, London, United Kingdom.
Torsten TonnExperimental Transfusion Medicine, Medical Faculty Carl Gustav Carus, Technical University Dresden, Germany; Institute for Transfusion Medicine Dresden, German Red Cross Blood Donation Service North-East, Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Dresden, Germany.
German Red Cross · DEKing's College London · GBUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed at investigating the nature of SARS-CoV-2-specific immunity in patients with mild COVID-19 and sought to identify parameters most relevant for the generation of neutralizing antibody responses in convalescent COVID-19 patients. In the majority of the examined patients a cellular as well as humoral immune response directed to SARS-CoV-2 was detected. The finding of an anti-SARS-CoV-2-reactive cellular immune response in healthy individuals suggests a pre-existing immunity to various common cold HCoVs which share close homology with SARS-CoV-2. The humoral immunity to the S protein of SARS-CoV-2 detected in convalescent COVID-19 patients correlates with the presence of SARS-CoV-2-reactive CD4

Indexed as

Antibodies, ViralCD4-Positive T-LymphocytesCOVID-19Immunity, HumoralHumansImmunoglobulin GSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Alpha- and BetacoronavirusCommon cold human CoronavirusCOVID-19Humoral immunitySARS-CoV-2SARS-CoV-2-reactive T-cell immunity

Identifiers

PMID36174771
PMCPMC9512529
OpenAlexW4297399556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.