ArticleDevelopmental cognitive neuroscience2022
Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development.
Article in Developmental cognitive neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
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- Growing together: Dynamic connectivity between developmentally sensitive regions serving verbal working memory in children and adolescents.The Journal of physiology · 2025Article
- Developmental shifts in testosterone levels are associated with alterations in the neural oscillatory dynamics serving selective attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Interactive effects of social media use and puberty on resting-state cortical activity and mental health symptoms.Developmental cognitive neuroscience · 2025Article
- Chronic Cannabis users exhibit altered oscillatory dynamics and functional connectivity serving visuospatial processing.Journal of psychopharmacology (Oxford, England) · 2024Article
- Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth.Human brain mapping · 2024Article
- Developmental changes in endogenous testosterone have sexually-dimorphic effects on spontaneous cortical dynamics.Human brain mapping · 2023Article
- Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks.Development and psychopathology · 2023Article
- Developmental differences in functional organization of multispectral networks.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spontaneous cortical dynamics from the first years to the golden years.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Frontoparietal oscillatory dynamics support the development of fluid reasoning in children and adolescents.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Dehydroepiandrosterone (DHEA) production is closely associated with the first pubertal hormonal event, adrenarche. Few studies have documented the relationships between DHEA and functional brain development, with even fewer examining the associations between DHEA and spontaneous cortical activity during the resting-state. Thus, whether DHEA levels are associated with the known developmental shifts in the brain's idling cortical rhythms remains poorly understood. Herein, we examined spontaneous cortical activity in 71 typically-developing youth (9-16 years; 32 male) using magnetoencephalography (MEG). MEG data were source imaged and the power within five canonical frequency bands (delta, theta, alpha, beta, gamma) was computed to identify spatially- and spectrally-specific effects of salivary DHEA and DHEA-by-sex interactions using vertex-wise ANCOVAs. Our results indicated robust increases in power with increasing DHEA within parieto-occipital cortices in all frequency bands except alpha, which decreased with increasing DHEA. In the delta band, DHEA and sex interacted within frontal and temporal cortices such that with increasing DHEA, males exhibited increasing power while females showed decreasing power. These data suggest that spontaneous cortical activity changes with endogenous DHEA levels during the transition from childhood to adolescence, particularly in sensory and attentional processing regions. Sexually-divergent trajectories were only observed in later-developing frontal cortical areas.
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