Evidence map›Paper›PMID 36174211›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Chronic Obstructive Pulmonary Disease and Cigarette Smoke Lead to Dysregulated Mucosal-associated Invariant T-Cell Activation.

Megan E Huber, Emily Larson, Taylor N Lust, Chelsea M Heisler, Melanie J Harriff

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Mucosal-associated invariant T-cells in pulmonary pathophysiology.Current opinion in pulmonary medicine · 2025
    Review
  5. Article
  6. Cigarette smoke components modulate the MR1-MAIT axis.The Journal of experimental medicine · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. COPD and Immune Checkpoint Inhibitors for Cancer: A Literature Review.International journal of chronic obstructive pulmonary disease · 2024
    Review
  12. Article
  13. MAIT cells and the microbiome.Frontiers in immunology · 2023
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Megan E HuberDepartment of Molecular and Microbial Immunology and.ORCID 0000-0003-4017-5393
Emily LarsonPortland Veterans Affairs Research Foundation, Portland, Oregon; and.
Taylor N LustDivision of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon.
Chelsea M HeislerDivision of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon.
Melanie J HarriffDepartment of Molecular and Microbial Immunology and.ORCID 0000-0002-1461-5351
Oregon Health & Science University · USPortland VA Research Foundation · US

Funding

Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Distinct pathways for MR1 antigen presentation upon infection with intracellular versus extracellular pathogensR01AI129976 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARRIFF, MELANIE J · 2017 to 2021
$1.9M
Deltavision RT Image Restoration System for Established Research Core FacilityS10RR023432 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLER, THOMAS J · 2007 to 2007
$365k
Impact of COPD on Lung-Resident MAIT Cell Frequency, Function and Recognition of Bacterial InfectionI01CX001562 · VA · PORTLAND VA MEDICAL CENTER · PI HARRIFF, MELANIE J · 2018 to 2021
–
CSRD VA I01 CX001562NCRR NIH HHS S10 RR023432NHLBI NIH HHS T32 HL083808NIAID NIH HHS R01 AI129976NIH HHS R01 AI129976
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8

Indexed as

Cigarette SmokingMucosal-Associated Invariant T CellsPulmonary Disease, Chronic ObstructiveHumansInflammationLungchronic obstructive pulmonary diseasecigarette smokeMAIT cellsMR1Streptococcus pneumoniae

Identifiers

PMID36174211
PMCPMC9817907
OpenAlexW4297983816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.