ArticlePloS one2022
Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Fasting requires Peroxiredoxin 2 and Peroxiredoxin 6 to coordinate redox dependent mitochondrial and lipid remodelling in Caenorhabditis elegans.Redox biology · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
- RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation inbioRxiv : the preprint server for biology · 2025Article
- Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- Neuronal PRDX-2-Mediated ROS Signaling Regulates Food Digestion via peripheral UPRNature communications · 2024Article
- TWISP: a transgenic worm for interrogating signal propagation in Caenorhabditis elegans.Genetics · 2024Article
- Reactive oxygen species drive foraging decisions in Caenorhabditis elegans.Redox biology · 2023Article
- Article
- TWISP: A Transgenic Worm for Interrogating Signal Propagation inbioRxiv : the preprint server for biology · 2023Article
- LITE-1 mediates behavioral responses to X-rays inFrontiers in neuroscience · 2023Article
- Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans.Nature communications · 2022Article
- Left-right asymmetry in oxidative stress sensing neurons inmicroPublication biology · 2022Article
- Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide.PLoS pathogens · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Environmental oxidative stress threatens cellular integrity and should therefore be avoided by living organisms. Yet, relatively little is known about environmental oxidative stress perception. Here, using microfluidics, we showed that like I2 pharyngeal neurons, the tail phasmid PHA neurons function as oxidative stress sensing neurons in C. elegans, but display different responses to H2O2 and light. We uncovered that different but related receptors, GUR-3 and LITE-1, mediate H2O2 signaling in I2 and PHA neurons. Still, the peroxiredoxin PRDX-2 is essential for both, and might promote H2O2-mediated receptor activation. Our work demonstrates that C. elegans can sense a broad range of oxidative stressors using partially distinct H2O2 signaling pathways in head and tail sensillae, and paves the way for further understanding of how the integration of these inputs translates into the appropriate behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.