Evidence map›Paper›PMID 36173930›Full record

ArticleChembiochem : a European journal of chemical biology2022

Covalent Modification of Bromodomain Proteins by Peptides Containing a DNA Damage-Induced, Histone Post-Translational Modification.

Marco Paolo Jacinto, David Heidenreich, Susanne Müller, Marc M Greenberg

Open access · greenAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Marco Paolo JacintoChemistry, Johns Hopkins University, 3400 N. Charles St., 21218, Baltimore, MD, USA.
David HeidenreichInstitute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Susanne MüllerInstitute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Marc M GreenbergChemistry, Johns Hopkins University, 3400 N. Charles St., 21218, Baltimore, MD, USA.ORCID 0000-0002-5786-6118
Goethe University Frankfurt · DEJohns Hopkins University · US

Funding

How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and ApplicationsR35GM131736 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MARC M GREENBERG · 2019 to 2026
$4.3M
NIGMS NIH HHS R35 GM131736
6 · The paper itself

Abstract

An electrophilic 5-methylene-2-pyrrolone modification (K

Indexed as

HistonesTandem Mass SpectrometryAcetylationDNADNA DamageHeLa CellsHumansPeptidesProtein Processing, Post-TranslationalDNAHistonesPeptidescovalent protein modificationsDNA damagehistonesoxidative stresspost-translational modifications

Identifiers

PMID36173930
PMCPMC9675715
OpenAlexW4297995581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.