Evidence map›Paper›PMID 36173701›Full record

ReviewAnnual review of virology2022

Advances in Understanding Neuropathogenesis of Rift Valley Fever Virus.

Kaleigh A Connors, Amy L Hartman

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. The public health threat of emerging phenuiviruses.One health (Amsterdam, Netherlands) · 2025
    Review
  9. Research progress of mosquito-borne virus mRNA vaccines.Molecular therapy. Methods & clinical development · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. An Introduction to Rift Valley Fever Virus.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kaleigh A ConnorsCenter for Vaccine Research, School of Medicine; and Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; email: hartman2@pitt.edu.
Amy L HartmanCenter for Vaccine Research, School of Medicine; and Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; email: hartman2@pitt.edu.
University of Pittsburgh · US

Funding

Identification and Characterization of Entry Factors Critical for Rift Valley Fever Virus Infection and PathogenesisR01AI161765 · NIAID · WASHINGTON UNIVERSITY · PI AMARASINGHE, GAYA K., HARTMAN, AMY L · 2021 to 2025
$3.7M
Live-attenuated Rift Valley fever vaccines: comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetusesR01AI150792 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2020 to 2025
$3.7M
Neuroprotective anti-inflammatory drugs as a novel combination therapy for neurological Rift Valley FeverR01NS101100 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2017 to 2021
$1.7M
NIAID NIH HHS R01 AI150792NIAID NIH HHS R01 AI161765NINDS NIH HHS R01 NS101100
6 · The paper itself

Abstract

Rift Valley fever virus (RVFV) is an emerging arboviral pathogen that causes disease in both livestock and humans. Severe disease manifestations of Rift Valley fever (RVF) in humans include hemorrhagic fever, ocular disease, and encephalitis. This review describes the current understanding of the pathogenesis of RVF encephalitis. While some data from human studies exist, the development of several animal models has accelerated studies of the neuropathogenesis of RVFV. We review current animal models and discuss what they have taught us about RVFV encephalitis. We briefly describe alternative models that have been used to study other neurotropic arboviruses and how these models may help contribute to our understanding RVFV encephalitis. We conclude with some unanswered questions and future directions.

Indexed as

ArbovirusesEncephalitisRift Valley FeverRift Valley fever virusAnimalsHumansaerosolAfrican green monkeyarbovirusbunyavirusmonkeyratRift Valley feverviral encephalitis

Identifiers

PMID36173701
PMCPMC10316117
OpenAlexW4297996675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.