Evidence map›Paper›PMID 36173561›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Inspiratory muscle training in addition to conventional physical rehabilitation in hospitalized patients undergoing hematopoietic stem cell transplantation: a randomized controlled trial.

Leonardo Barbosa Almeida, Mateus Camaroti Laterza, Maria Urbana Pinto Brandão Rondon, Luciana Diniz Nagem Janot de Matos, Catherine L Granger, Linda Denehy, Cristino Carneiro Oliveira, Patricia Fernandes Trevizan, Daniel Godoy Martinez

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03373526 (Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03373526 naunknown statusnot on this map

Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation

TypeinterventionalSponsorDaniel Godoy MartinezRan2017 to 2019Enrolled50ConditionsLymphoma, Myeloma, Leukemia, Aplastic AnemiaArmsInspiratory Muscle Training, Aerobic Training
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Leonardo Barbosa AlmeidaCardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil. almeidalb@hotmail.com.ORCID http://orcid.org/0000-0002-3840-9042
Mateus Camaroti LaterzaCardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil.ORCID http://orcid.org/0000-0002-3984-4951
Maria Urbana Pinto Brandão RondonSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-4134-6126
Luciana Diniz Nagem Janot de MatosHospital Israelita Albert Einstein, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9852-3293
Catherine L GrangerDepartment of Physiotherapy, University of Melbourne, Melbourne, Australia.ORCID http://orcid.org/0000-0001-6169-370X
Linda DenehyDepartment of Physiotherapy, University of Melbourne, Melbourne, Australia.ORCID http://orcid.org/0000-0002-2926-8436
Cristino Carneiro OliveiraPostgraduate Research Program On Rehabilitation Sciences and Physical Function Performance, Federal University of Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0001-6546-0225
Patricia Fernandes TrevizanCardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil.ORCID http://orcid.org/0000-0001-5517-8285
Daniel Godoy MartinezCardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil.ORCID http://orcid.org/0000-0003-0034-7963
Universidade Federal de Juiz de Fora · BRThe University of Melbourne · AUHospital Israelita Albert Einstein · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 313152/2020-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 425702/2018-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00435-18Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02877-18
6 · The paper itself

Abstract

purposeTo investigate the effect of inspiratory muscle training (IMT) in addition to conventional physical rehabilitation on muscle strength, functional capacity, mobility, hemodynamics, fatigue, and quality of life in hospitalized patients undergoing hematopoietic stem cell transplantation (HSCT).

methodsWe conducted a randomized controlled trial in 57 inpatients with hematological diseases undergoing HSCT. Conventional inpatient physical rehabilitation was delivered to the IMT (n = 27) and control (CON; n = 30) groups according to usual care, and the first group additionally performed IMT. The IMT was prescribed according to clinical and laboratory parameters at 40% of maximal inspiratory pressure (MIP), 5 days/week throughout the hospitalization, in sessions of 10-20 min. The primary outcome was MIP and the secondary outcomes were maximal expiratory pressure (MEP), peripheral muscle strength (handgrip and sit-to-stand tests), functional capacity (6-min step test), mobility (timed up and go test), blood pressure, quality of life (EORTC-QLQ-C30), and fatigue (FACT-F) at admission and hospital discharge.

resultsThe population was predominately autologous HSCT. The IMT group significantly increased the MIP (P < 0.01) and decreased both fatigue (P = 0.01) and blood pressure (P < 0.01) compared with control. No differences were found between admission and hospital discharge in peripheral and expiratory muscle strength, functional capacity, mobility, and quality of life in both groups (P > 0.05).

conclusionsOur results support the effectiveness of IMT as part of rehabilitation for HSCT inpatients, improving inspiratory muscle strength, and reducing fatigue and blood pressure.

trial registrationNCT03373526 (clinicaltrials.gov).

Indexed as

Hematopoietic Stem Cell TransplantationRespiratory MusclesBreathing ExercisesFatigueHand StrengthHumansMuscle StrengthPostural BalanceQuality of LifeTime and Motion StudiesBlood pressureBreathing exercisesFatigueHematopoietic stem cell transplantationRehabilitationRespiratory muscles

Identifiers

PMID36173561
OpenAlexW4297964472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.