Evidence map›Paper›PMID 36173506›Full record

ArticleSleep & breathing = Schlaf & Atmung2023

The impact of obstructive sleep apnea on exercise capacity in a cardiac rehabilitation program.

C Sonners, C N Schmickl, J Raphelson, A V Sykes, E G Roberts, I Swiatkiewicz, A Malhotra, P R Taub

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

C SonnersDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland. csonners@health.ucsd.edu.ORCID 0000-0002-1053-9080
C N SchmicklDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
J RaphelsonDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
A V SykesDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
E G RobertsDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
I SwiatkiewiczDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
A MalhotraDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
P R TaubDepartment of Cardiology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
Nicolaus Copernicus University · PLUC San Diego Health System · US

Funding

Impact of Time-Restricted Feeding (TRF) on Glucose Homeostasis and Mitochondrial Function in Patients with Metabolic SyndromeR01DK118278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pam Rajendran Taub · 2018 to 2026
$5.3M
HL-132: Increasing Adherence to Guideline-Based Exercise Therapy For Chronic Heart FailureR01HL136407 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 2018 to 2022
$4.0M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Acetazolamide to Improve Clinically Important Outcomes in Obstructive Sleep Apnea Patients with a High Loop Gain EndotypeK23HL161336 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christopher Nikolaus Schmickl · 2022 to 2026
$863k
NHLBI NIH HHS K23 HL161336NHLBI NIH HHS R01 HL136407NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS T32 HL134632NIA NIH HHS R01 AG063925NIDDK NIH HHS R01 DK118278
6 · The paper itself

Abstract

purposeCardiac rehabilitation (CR) improves clinical outcomes in patients with cardiovascular disease (CDV). Patients with CVD often have multiple comorbidities, including obstructive sleep apnea (OSA), potentially affecting their ability to participate and achieve functional improvement during CR. We aimed to test the hypothesis that OSA reduces peak exercise capacity (EC) in patients undergoing CR and to explore if OSA treatment modifies this relationship.

methodsData from a retrospective cohort of CR patients was analyzed. OSA was defined as a respiratory event index > 5/h or physician diagnosis. Patients with OSA were considered "treated" if using continuous positive airway pressure regularly during the CR period. Change in METs was the primary study outcome.

resultsAmong 312 CR patients, median age of 67 years, 103 (33%) had known OSA (30 treated, 73 untreated). Patients with OSA vs. those with no OSA were more likely to be obese and male; otherwise, groups were similar. Compared with the no OSA group, patients with OSA had lower pre-CR METs (3.3 [2.9-4.5] vs. 3.9 [3.1-5], P = .01) and lower post-CR METs (5.3 [4-7] vs. 6 [4.6-7.6], P = .04), but achieved a similar increase in METs post-CR (1.8 [0.6-2.6] vs. 2.0 [0.9-3], P = .22). Furthermore, compared to no OSA, pre-CR and post-CR METs tended to be similar in patients with treated OSA, but lower in untreated patients, with similar increases in METs across all groups, even when adjusting for covariates via multivariable regression.

conclusionOSA is prevalent in patients with CVD undergoing CR. CR substantially improves exercise capacity independent of OSA status, but screening for-and treatment of-OSA may improve the absolute exercise capacity achieved through CR.

Indexed as

Cardiac RehabilitationCardiovascular DiseasesSleep Apnea, ObstructiveAgedExercise ToleranceHumansMaleRetrospective StudiesCardiac rehabilitationExercise capacityObstructive sleep apnea

Identifiers

PMID36173506
PMCPMC10050218
OpenAlexW4297965245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.