Evidence map›Paper›PMID 36173235›Full record

Trial reportDiabetes technology & therapeutics2022

A Multicenter Randomized Trial Evaluating Fast-Acting Insulin Aspart in the Bionic Pancreas in Adults with Type 1 Diabetes.

Roy W Beck, Steven J Russell, Edward R Damiano, Firas H El-Khatib, Katrina J Ruedy, Courtney Balliro, Zoey Li, Peter Calhoun

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Diabetes technology & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04200313 (The Insulin-Only Bionic Pancreas Pivotal Trial), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04200313 nacompletednot on this map

The Insulin-Only Bionic Pancreas Pivotal Trial: Testing the iLet in Adults and Children With Type 1 Diabetes

TypeinterventionalSponsorJaeb Center for Health ResearchRan2020 to 2022Enrolled440ConditionsDiabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 1ArmsBionic Pancreas (BP) with Aspart or Lispro, Bionic Pancreas with Fiasp (BPFiasp), Usual Care (UC), BP Guidance Insulin Dosing
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  14. A Review of Real-World Evidence About the Use of Automated Insulin Delivery Systems in People With Type 1 Diabetes.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Roy W BeckJAEB Center for Health Research, Tampa, Florida, USA.ORCID 0000-0002-5194-8446
Steven J RussellMassachusetts General Hospital, Boston, Massachusetts, USA.
Edward R DamianoDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts.
Firas H El-KhatibBeta Bionics, Concord, Massachusetts, USA.
Katrina J RuedyJAEB Center for Health Research, Tampa, Florida, USA.
Courtney BalliroMassachusetts General Hospital, Boston, Massachusetts, USA.
Zoey LiJAEB Center for Health Research, Tampa, Florida, USA.
Peter CalhounJAEB Center for Health Research, Tampa, Florida, USA.ORCID 0000-0002-5325-7200
Jaeb Center for Health Research · USMassachusetts General Hospital · USBoston University · USConcord Consortium · US

Funding

Final clinical studies for submission of a pre-market approval application to the FDA for a Bionic Pancreas that automates type 1 diabetes managementUC4DK108612 · NIDDK · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BECK, ROY W., DAMIANO, EDWARD · 2015 to 2016
$13.5M
NIDDK NIH HHS UC4 DK108612
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 1HypoglycemiaAdolescentAdultAgedAged, 80 and overBionicsBlood GlucoseBlood Glucose Self-MonitoringGlycated HemoglobinHumansHypoglycemic AgentsInsulinInsulin AspartInsulin LisproMiddle AgedBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinInsulin AspartInsulin LisproAdultArtificial pancreasAutomated insulin deliveryBionic pancreasEvaluationFast-acting insulinType 1 diabetes

Identifiers

PMID36173235
PMCPMC9529301
OpenAlexW4298013182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.