ArticleEMBO molecular medicine2022
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation.
Article in EMBO molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Invasive non-typhoidal Salmonella infections in China (1961-2024): a retrospective systematic analysis of multicentre case reports.Journal of global health · 2026Pooled it
- One Health approach probes zoonotic non-typhoidal Salmonella infections in China: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Nationwide trends and features of human salmonellosis outbreaks in China.Emerging microbes & infections · 2024Pooled it
- One Health genomics reveals niche-specific lineage replacement inNational science review · 2026Article
- Developing a novel TaqMan qPCR assay for optimizingThe veterinary quarterly · 2025Article
- Laboratory epidemiology ofOne health (Amsterdam, Netherlands) · 2025Article
- Illuminating the genomic frontier of invasive non-typhoidal Salmonella infections.Clinical and translational medicine · 2025Article
- Microbiological Monitoring and Microbial Susceptibility ofAntibiotics (Basel, Switzerland) · 2025Article
- Evaluating the Aquatic Environment as a Reservoir forMicroorganisms · 2025Article
- Article
- Ecological prevalence and genomic characterization of Salmonella isolated from selected poultry farms in Jiangxi province, China.Poultry science · 2025Article
- Genomic census of invasive nontyphoidal Salmonella infections reveals global and local human-to-human transmission.Nature medicine · 2025Article
- Genomic and resistome analysis ofOne health (Amsterdam, Netherlands) · 2025Article
- Bergeyella zoohelcum: A first case report of its association with respiratory diseases in swine in China.Veterinary research communications · 2025Article
- Avian-specificeLife · 2025Article
- Predicting antimicrobial resistance inComputational and structural biotechnology journal · 2024Article
- Article
- A global genome dataset for Salmonella Gallinarum recovered between 1920 and 2024.Scientific data · 2024Article
- The Evolution of Vaccines Development acrossVaccines · 2024Review
- Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with ~15% case fatality in many countries. However, the mechanism by which iNTS emerged in China remains unaddressed. We conducted clinical investigations of iNTS infection with recurrent treatment failure, caused by underreported Salmonella enterica serovar Livingstone (SL). Genomic epidemiology demonstrated five clades in the SL population and suggested that the international animal feed trade was a likely vehicle for their introduction into China, as evidenced by multiple independent transmission incidents. Importantly, isolates from Clade-5-I-a/b, predominant in China, showed an invasive nature in mice, chicken and zebrafish infection models. The antimicrobial susceptibility testing revealed most isolates (> 96%) in China are multidrug-resistant (MDR). Overall, we offer exploiting genomics in uncovering international transmission led by the animal feed trade and highlight an emerging hypervirulent clade with increased resistance to frontline antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.