ArticleAsian Pacific journal of cancer prevention : APJCP2022
A Comprehensive Evaluation of Single Isocenter Multiple Target SRS Plans and the Analytical Relationship between Plan Quality Indices with the Number and Volume of Targets.
Article in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
- Pooled it
- Single-Isocenter Multiple-Target SRS Planning of Five to Ten Brain Metastases Using 5 mm Multileaf Collimator: Relationship between Prescription Dose, Number and Volume of Targets.Asian Pacific journal of cancer prevention : APJCP · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the relationship of plan quality indices with the number and volume of target for 5 to 10 brain metastases treated with LINAC-based Single Isocenter Multiple Target (SIMT) Stereotactic radiosurgery (SRS) planning and to determine the maximum volume of spherical targets treated without exceeding the normal tissue tolerances.
methodsSpherical targets of 5 to 10 numbers per plan, with individual target volumes ranging from 0.025 cc to 11.5 cc, were simulated with randomly drawn planning target volumes (PTVs) within the brain. SIMT SRS plans were generated for the 21 Gy prescription dose with a 6 MV Flattening Filter Free photon beam. Target coverage, organ at risk sparing, plan quality indices, R50%, and gradient measure were studied. Mean brain dose, V12 for Brain minus PTV (BmP), V10, V12, V15, V18, V20, and V24 for brain volume were evaluated. Equations relating the gradient index, mean brain dose, and V12 (BmP) to the given number and volume of the targets were constructed.
resultsPTV coverage D98 was 98.77 ± 1.37 %. The mean CIRTOG, QRTOG, HIRTOG, CIP, GI, and R50% of the individual targets were 1.02 ± 0.08, 0.94 ± 0.02, 1.49 ± 0.11, 0.91 ± 0.06, 4.74 ± 2.3, and 4.95 ± 2.67, respectively. The gradient measure achieved was in the range of 0.49 to 1.35 cm. The mean brain dose was in the range of 1.62 to 6.69 Gy. The mean V12 (BmP) per target obtained was 3.85 ± 2.83 cc.
conclusionEquations relating the number and volume of targets to the gradient measure, mean brain dose, V12 (BmP), and V10-24 can serve as a baseline for multiple brain metastases SIMT planning. The target volume for 5, 6, 7, 8, 9, and 10 targets that can be treated without exceeding V12 (BmP) is 6, 5, 4.7, 4, 3.7, and 3.4 cc, respectively, for the 21 Gy prescription dose.
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