Evidence map›Paper›PMID 36172629›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

PET imaging studies to investigate functional expression of mGluR2 using [

Gengyang Yuan, Maeva Dhaynaut, Nicolas J Guehl, Ramesh Neelamegam, Sung-Hyun Moon, Xiying Qu, Pekka Poutiainen, Sepideh Afshar, Georges El Fakhri, Marc D Normandin and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Distribution of [Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  4. Synthesis and Characterization of 5-(2-Fluoro-4-[Journal of medicinal chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Gengyang YuanGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Maeva DhaynautGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Nicolas J GuehlGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Ramesh NeelamegamGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Sung-Hyun MoonGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Xiying QuGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Pekka PoutiainenDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland.
Sepideh AfsharGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Anna-Liisa BrownellGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, MA 02114, USA.
Harvard University · USMassachusetts General Hospital · USGordon Center for Medical Imaging · USKuopio University Hospital · FI

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Positive Allosteric Modulators as PET Imaging Ligans for mGluR4R01NS100164 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2020
$3.7M
Designing group specific PET ligands for mGluR2R01EB021708 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2019
$2.2M
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
F-18 SynthesizerS10RR023452 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2007 to 2007
$500k
Gamma counter and continuous blood sampler for quantitative PET imagingS10OD018035 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES, NORMANDIN, MARC DAVID · 2014 to 2014
$144k
NCRR NIH HHS S10 RR023452NIBIB NIH HHS P41 EB022544NIBIB NIH HHS R01 EB021708NIH HHS S10 OD018035NIH HHS S10 OD025234NINDS NIH HHS R01 NS100164
6 · The paper itself

Abstract

Metabotropic glutamate receptor 2 (mGluR2) has been extensively studied for the treatment of various neurological and psychiatric disorders. Understanding of the mGluR2 function is pivotal in supporting the drug discovery targeting mGluR2. Herein, the positive allosteric modulation of mGluR2 was investigated via the

Indexed as

Receptors, Metabotropic GlutamateAnimalsCricetinaeCricetulusPositron-Emission TomographyRatsRats, Sprague-Dawleymetabotropic glutamate receptor 2Receptors, Metabotropic GlutamateMetabotropic glutamate receptor 2non-human primatepositive allosteric modulatorpositron emission tomographyrodent

Identifiers

PMID36172629
PMCPMC9903221
OpenAlexW4297503474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.