ArticleInfection and drug resistance2022
Diagnostic and Prognostic Value of Interleukin-6 in Emergency Department Sepsis Patients.
Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- IL-6 Baseline Values and Dynamic Changes in Predicting Sepsis Mortality: A Systematic Review and Meta-Analysis.Biomolecules · 2025Pooled it
- The impact of ulinastatin on lymphocyte apoptosis and autophagy in sepsis patients.Scientific reports · 2024Trial
- Role of Matrix Metalloproteinases and Tissue Inhibitors in Sepsis Pathogenesis.Medical sciences (Basel, Switzerland) · 2026Article
- Diagnostic accuracy of PCT, IL-6, and MR-ProADM for early identification of sepsis in the emergency department.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Observational
- A Mini-Review of Point-of-Care C-Reactive Protein Testing in Sepsis in the Emergency Department.EJIFCC · 2026Review
- The Diagnostic and Prognostic Value of Procalcitonin and High-Sensitivity C-Reactive Protein in Early-Stage Burn Sepsis: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Nomograms to predict outcome for patients undergoing venoarterial extracorporeal membrane oxygenation treatment for septic shock.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Interplay of IL-6, GDF-15 and Sarcopenia in Patients With Bladder Cancer Undergoing Radical Cystectomy and Its Implications on Survival.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Recent advances in biomarkers for detection and diagnosis of sepsis and organ dysfunction: a comprehensive review.European journal of medical research · 2025Review
- A LASSO-based integrative model of serum biomarkers and gene polymorphisms for predicting poor sepsis prognosis.Biomarkers in medicine · 2025Article
- Article
- Predictive value of combined detection of blood Urea nitrogen and Neutrophil-to-lymphocyte ratio for identifying severe pneumonia complicated with sepsis in neonates.BMC infectious diseases · 2025Article
- Point of care sepsis diagnosis: Exploring microfluidic techniques for sample preparation, biomarker isolation, and detection.Biomicrofluidics · 2025Review
- FLIPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- The impact of tocilizumab treatment on the severity of inflammation and survival rates in sepsis is significantly influence by the timing of administration.Inflammopharmacology · 2025Article
- The Role of Monocyte Distribution Width (MDW) in the Prediction of Death in Adult Patients with Sepsis.Microorganisms · 2025Article
- Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study.Journal of intensive care · 2025Article
- Predictive Value of IL-6 and PDGF-AA for 28-Day Mortality Risk in Critical Ill Patients.International journal of general medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The objective of this study was to explore the diagnostic and prognostic value of interleukin-6 (IL-6) in sepsis patients presenting to the emergency department. Patients and Methods: A total of 128 patients who visited the emergency department of West Hospital of Beijing Chaoyang Hospital, affiliated to Capital Medical University, from November 2021 to February 2022 were subjected to this study. According to Sepsis-3.0 diagnostic criteria for sepsis, patients were divided into non-sepsis group (65 cases) and sepsis group (63 cases). Demographic data and clinical characteristics of the two patient groups were compared. Serum levels of biomarkers including IL-6, blood urea nitrogen (BUN), and lactic acid (Lac) were compared with Sequential Organ Failure Assessment (SOFA) and Glasgow Coma Scale (GCS) scores. Logistic regression was used to analyze independent risk factors and Receiver Operating Characteristic Curve (ROC) method was used to analyze the Area Under the Curve (AUC) to determine the diagnostic and prognostic value of markers. Results: Compared with non-sepsis patients, levels of IL-6, PCT, CRP and BUN were significantly higher in sepsis patients (10.84 (4.41-27.01): 92.22 (21.53-201.12), 0.03 (0.01-0.1):0.49 (0.08-3.1), 8.3 (0.5-31.8):39.8(10.3-98.6), 7.01 (4.90-11.74):13.03 (6.93-25.99), all Conclusion: IL-6 is an independent predictor of sepsis diagnosis, and the combination of blood BUN and MAP has superior diagnostic performance. Lac, age, and SOFA score could effectively predict clinical outcomes in patients with sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.