ArticleFrontiers in cardiovascular medicine2022
Education level may modify the association between cardiac index and cognitive function among elders with normal ejection function.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Role of characteristic impedance in carotid stiffness and cognitive dysfunction: interaction with proximal aortic stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026Article
- Association of education level and depression with cognitive decline: findings from the examining cognitive health outcomes in heart failure study.Frontiers in cardiovascular medicine · 2025Article
- Aortic Characteristic Impedance and Suspected Mild Cognitive Impairment in a Community-Based Healthy Population.Journal of the American Heart Association · 2024Article
- Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder.Frontiers in aging neuroscience · 2024Article
- Level of cognitive functioning among elderly patients in urban area of Bangladesh: A cross-sectional study.PloS one · 2024Article
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Authors and funding
8 authors.
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Abstract
Background: Lower cardiac index (CI) in elders has been associated with incident dementia, and higher CI has protectively effect with brain aging. In the present study, we investigated the modulating effects of education level and arterial stiffness on the association between CI and cognitive function among older adults. Methods: A total of 723 elders (≥60 years, 50.1% women) with normal left ventricular ejection fraction (≥50%) were identified from the Cardiovascular Diseases Risk Factor Two-Township Study. CI was calculated from the Doppler-derived stroke volume. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (CFPWV) and global cognitive function by using the Mini-Mental Short Examination (MMSE). Education level was determined by years of formal education. Results: In linear regression analysis adjusting for age, sex, formal years of education, and CFPWV, CI was significantly positively associated with MMSE (BETA=0.344±0.130, Conclusion: In elders with normal ejection fraction, a higher CI was associated with a lower risk of cognitive function impairment, independent of arterial stiffness, mainly in subjects with a lower education level and possibly a smaller cognitive reserve.
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