ArticleFrontiers in cardiovascular medicine2022
Association of the systemic immune-inflammation index with all-cause mortality in patients with arteriosclerotic cardiovascular disease.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Systemic immune-inflammation index as a novel biomarker for metabolic syndrome: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Pooled it
- Preoperative Naples Prognostic Score and outcomes after isolated coronary artery bypass grafting: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Association Between Systemic Immune-Inflammation Index and Thyroid Function: A Cross-Sectional Population-Based Study.International journal of endocrinology · 2026Article
- Clinical Manifestations and Risk Factors of Osteoporosis in Patients with Type 2 Diabetes Mellitus.Journal of inflammation research · 2026Article
- Autonomic-inflammatory crosstalk in diabetic atherogenesis: a neuroimmune triad (HRV-LMR-hsCRP) predicts carotid plaque risk in type 2 diabetes.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Association between systemic immune-inflammation index and disease activity score 28 in patients with rheumatoid arthritis: a cross-sectional study.Scientific reports · 2025Article
- Association between triglyceride-glucose index combined with a body shape index and atherosclerotic cardiovascular disease risk varies by glycemic status: insights from the UK Biobank.Cardiovascular diabetology · 2025Article
- Can inflammatory indices predict myringosclerosis?Saudi medical journal · 2025Article
- The relationship of Systemic Inflammatory Index with asthma in adults: A retrospective cross-sectional study.The Journal of international medical research · 2025Article
- Mediating role of SII in the association between LC9 and overactive bladder.Scientific reports · 2025Article
- Correlation analysis of systemic immune-inflammation index values and arthritis risk in adults.The Journal of international medical research · 2025Article
- Can We Determine Osteoarthritis Severity Based on Systemic Immuno-Inflammatory Index?Diagnostics (Basel, Switzerland) · 2025Article
- Analysis of the association between long-term exposure to low-dose ionizing radiation and dyslipidemia and its components in medical radiologists: The mediating role of inflammatory markers.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- New marker for the detection of pre-retinopathy in patients with type 1 diabetes mellitus: systemic immuno-inflammation index.BMC ophthalmology · 2025Article
- Association between systemic immune-inflammation index and chronic bronchitis: NHANES 2001-2018.Scientific reports · 2025Article
- A novel indicator of all-cause mortality in acute coronary syndrome: the CALLY index.Biomarkers in medicine · 2025Article
- Prognostic value of the preoperative prognostic nutritional and systemic immunoinflammatory indexes in patients with colorectal cancer.BMC cancer · 2025Article
- Association of the systemic immune-inflammation index with clinical outcomes in acute myocardial infarction patients with hypertension.BMC immunology · 2025Article
- Future Directions in Quantitative SPECT-CT Evaluation of Cardiac Transthyretin Amyloidosis: Correlation with Clinical and Morphological Parameters.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Systemic immune-inflammation index (SII), derived from blood cell counts of circulating platelets, neutrophils, and lymphocytes, has been identified as a novel inflammatory and prognostic marker. However, the clinical value of SII in patients with arteriosclerotic cardiovascular disease (ASCVD) had not been further explored. Thus, this study is designed to explore the associations of SII with mortality in ASCVD individuals. Methods: All individuals with ASCVD aged ≥20 years were included from the National Health and Nutritional Examination Surveys (NHANES) 2005-2014 and followed for survival until 31 December 2019. Multivariable Cox analysis investigated the associations between SII, evaluated as a continuous variable with splines, as categorical ones (quartiles), and the all-cause death. To demonstrate the association between SII and mortality, subgroup analysis, restricted cubic spline along with piecewise linear regression were also conducted. Results: A total of 2,595 participants (57.8% men) were included. During a median of 7.7 years of follow-up, 1,122 deaths due to all-cause were recorded. After adjusting for multiple confounders, when compared with the patients in quartile 1 (SII ln transform), those in quartile 4 had a 46% increased risk for all-cause death [hazard ratio (HR) = 1.46, 95% confidence interval (CI) = 1.22-1.75]. As a continuous variable, each unit of raised ln-SII was associated with a 24% increased risk of all-cause death (HR = 1.24, 95% CI = 1.10-1.38). In the restricted cubic spline regression model, the relationship between ln-SII and all-cause death was non-linear. The cutoff value of ln-SII for mortality was 6.57 and those with a higher than the threshold point had a 1.25-fold risk of mortality. No significant difference was noted below the threshold points. Conclusion: An association was detected between the baseline ln-SII and all-cause mortality in a United States ASCVD population. Increased SII is associated with poor survival in individuals with ASCVD.
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