Evidence map›Paper›PMID 36172540›Full record

ArticleFrontiers in medicine2022

Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis: Analysis of an international cohort of 2,335 patients.

Márk Félix Juhász, Nelli Farkas, Andrea Szentesi, Andrzej Wedrychowicz, Andreia Florina Nita, Natália Lásztity, Alexandra Tészás, István Tokodi, Áron Vincze, Bálint Eross and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Márk Félix JuhászInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
Nelli FarkasInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
Andrea SzentesiInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
Andrzej WedrychowiczDepartment of Pediatrics, Gastroenterology and Nutrition, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
Andreia Florina NitaDepartment of Paediatrics, Grigore Alexandrescu Emergency Hospital for Children, Bucharest, Romania.
Natália LásztityDepartment of Pediatrics, Szent János's Hospital and North Buda Unified Hospitals, Budapest, Hungary.
Alexandra TészásDepartment of Paediatrics, University of Pécs Clinical Centre, Pécs, Hungary.
István TokodiSzent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary.
Áron VinczeDivision of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
Bálint ErossInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
Ferenc IzbékiSzent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary.
László CzakóDepartment of Medicine, University of Szeged, Szeged, Hungary.
Mária PappDivision of Gastroenterology, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary.
Péter HegyiInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
Andrea PárniczkyInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
University of Pecs · HUSemmelweis University · HUFejér Megyei Szent György Egyetemi Oktató Kórház · HUBuda Health Center · HUClinical Emergency Hospital Bucharest · ROJagiellonian University · PLUniversity of Debrecen · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In pediatric acute pancreatitis (AP), a family history of pancreatic diseases is prognostic for earlier onset of recurrent AP (ARP) and chronic pancreatitis (CP). No evidence supports the same association in adult-onset pancreatitis. Age-specific reasons for familial aggregation are also unclear. We aimed to examine the prognostic role of pancreatic family history for ARP/CP and observe possible underlying mechanisms. Methods: We conducted a secondary analysis of the Hungarian Pancreatic Study Group's (HPSG) multicenter, international, prospective registry of patients with AP, both children and adults. We compared the positive family history and the negative family history of pancreatic diseases, in different age groups, and analyzed trends of accompanying factors. Chi-square and Fisher exact tests were used. Results: We found a higher rate of ARP/CP in the positive pancreatic family history group (33.7 vs. 25.9%, Conclusion: Positive family history most likely signifies genetic background in early childhood. During adolescence and early adulthood, alcohol consumption and smoking emerge-clinicians should be aware and turn to intervention in such cases. Contrary to current viewpoints, positive pancreatic family history is not a prognostic factor for ARP and CP in adults, so it should not be regarded that way.

Indexed as

acute pancreatitisfamily historygeneticharmful alcohol consumptionrecurrent pancreatitis

Identifiers

PMID36172540
PMCPMC9511134
OpenAlexW4295233324

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.