Evidence map›Paper›PMID 36172487›Full record

ArticleBioMed research international2022

Prognostic Analysis of LncRNA MCM3AP-AS1 in Colorectal Cancer and the Mechanism of Its Effect on Tumor Cell Activity.

Qi Song, Jinsuo Gao, Jinzhu Yang, Subash C B Gopinath, Lei Shen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Qi SongDepartment of Oncology, Anhui Medical University, Hefei Third Clinical College, The Third People's Hospital of Hefei, Hefei, Anhui 230022, China.
Jinsuo GaoDepartment of Oncology, Anhui Medical University, Hefei Third Clinical College, The Third People's Hospital of Hefei, Hefei, Anhui 230022, China.
Jinzhu YangDepartment of Oncology, Anhui Medical University, Hefei Third Clinical College, The Third People's Hospital of Hefei, Hefei, Anhui 230022, China.
Subash C B GopinathFaculty of Chemical Engineering Technology, Universiti Malaysia Perlis (UniMAP), 02600 Arau, Perlis, Malaysia.ORCID https://orcid.org/0000-0002-8347-4687
Lei ShenDepartment of Oncology, Anhui Medical University, Hefei Third Clinical College, The Third People's Hospital of Hefei, Hefei, Anhui 230022, China.ORCID https://orcid.org/0000-0001-7313-0955
Anhui Medical University · CNUniversiti Malaysia Perlis · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine the clinical prognostic significance of lncRNA MCM3AP-AS1 in colorectal cancer (CRC) and its preliminary mechanism, 43 CRC patients and 48 healthy individuals were analyzed. Peripheral blood MCM3AP-AS1 was quantified via qRT-PCR in CRC patients at admission and 2 h after surgery and in healthy individuals. Human colon cancer cells (HCT116 and SW480) were transfected with shRNAs targeting upregulation of MCM3AP-AS1 expression (named as sh-MCM3AP-AS1 group) and corresponding negative RNAs (named as sh-MCM3AP-AS1 group). Additionally, the cells were then treated either with 50 mM of the VEGF-specific inhibitor PTK787 (Selleck, USA) (named as inhibition group) or normal saline as a control (named as control group). Before therapy, CRC patients presented a higher MCM3AP-AS1 level than healthy individuals (

Indexed as

Colorectal NeoplasmsRNA, Long NoncodingAcetyltransferasesCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsPrognosisRNA, MessengerSaline SolutionVascular Endothelial Growth Factor AAcetyltransferasesIntracellular Signaling Peptides and ProteinsMCM3AP protein, humanRNA, Long NoncodingRNA, MessengerSaline SolutionVascular Endothelial Growth Factor A

Identifiers

PMID36172487
PMCPMC9512606
OpenAlexW4296458844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.