Evidence map›Paper›PMID 36172380›Full record

ArticleFrontiers in immunology2022

Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function.

Martin Wepler, Jonathan M Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Gröger and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Martin WeplerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Ulm, Germany.
Jonathan M PreussInstitute of Comparative Molecular Endocrinology (CME), Ulm University, Ulm, Germany.
Cornelia TilpImmunology and Respiratory, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
Martina KeckImmunology and Respiratory, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
Jochen BlenderImmunology and Respiratory, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
Ulrich WachterInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Tamara MerzInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Josef VogtInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Sandra KressInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Michael GrögerInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Andrea HoffmannInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Marina FinkInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Enrico CalziaInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Ute BurretInstitute of Comparative Molecular Endocrinology (CME), Ulm University, Ulm, Germany.
Peter RadermacherInstitute for Anesthesiologic Pathophysiology and Process Engineering, Ulm University, Ulm, Germany.
Jan P TuckermannInstitute of Comparative Molecular Endocrinology (CME), Ulm University, Ulm, Germany.
Sabine VettorazziInstitute of Comparative Molecular Endocrinology (CME), Ulm University, Ulm, Germany.
Universität Ulm · DEBoehringer Ingelheim (Germany) · DEUniversity Hospital Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We previously showed that attenuated glucocorticoid receptor (GR) function in mice (GR Methods: After 3 weeks of CS exposure, anesthetized and mechanically ventilated GR Results: Nor CS exposure neither attenuated GR function affected survival. Non-CS GR Conclusion: Whether less metabolic acidosis or increased lipolysis is the reason or the consequence for the trend towards lower catecholamine need in CS exposed GR

Indexed as

Cigarette SmokingLung DiseasesPulmonary Disease, Chronic ObstructiveShock, HemorrhagicAnimalsCatecholaminesCorticosteroneCytokinesGlucocorticoidsHypoxiaLactatesMiceNorepinephrineReceptors, GlucocorticoidCatecholaminesCorticosteroneCytokinesGlucocorticoidsLactatesNorepinephrineReceptors, Glucocorticoidcatecholaminescigarettes smoke exposureglucocorticoid receptor functionhemodynamic functionhemorrhagic shockinflammationmetabolic function

Identifiers

PMID36172380
PMCPMC9510589
OpenAlexW4296528087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.