Evidence map›Paper›PMID 36172130›Full record

ArticlebioRxiv : the preprint server for biology2022

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome.

Brian V Tsu, Rimjhim Agarwal, Nandan S Gokhale, Jessie Kulsuptrakul, Andrew P Ryan, Lennice K Castro, Christopher M Beierschmitt, Elizabeth A Turcotte, Elizabeth J Fay, Russell E Vance and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Brian V TsuDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
Rimjhim AgarwalDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
Nandan S GokhaleDepartment of Immunology, University of Washington; Seattle, WA, USA.
Jessie KulsuptrakulMolecular and Cellular Biology Graduate Program, University of Washington; Seattle, WA, USA.
Andrew P RyanDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
Lennice K CastroDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
Christopher M BeierschmittDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
Elizabeth A TurcotteDivision of Immunology and Pathogenesis, University of California, Berkeley; Berkeley, CA, USA.
Elizabeth J FayDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
Russell E VanceDivision of Immunology and Pathogenesis, University of California, Berkeley; Berkeley, CA, USA.
Jennifer L HydeDepartment of Microbiology, University of Washington; Seattle, WA, USA.
Ram SavanDepartment of Immunology, University of Washington; Seattle, WA, USA.
Patrick S MitchellDepartment of Microbiology, University of Washington; Seattle, WA, USA.
Matthew D DaughertyDepartment of Molecular Biology, University of California, San Diego; La Jolla, CA, USA.
University of California San Diego · USUniversity of Washington · USBerkeley College · USHoward Hughes Medical Institute · US

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI COX, JEFFERY S · 2004 to 2025
$45.5M
GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
Functional and Structural Dissection of Inflammasome ActivationR37AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUSSELL E VANCE · 2018 to 2026
$3.8M
Pathogen-driven evolution of innate antiviral defense mechanismsR35GM133633 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty · 2019 to 2026
$3.3M
Translation of evolution-guided insights for new models of human infectious diseaseDP2AI154432 · NIAID · UNIVERSITY OF WASHINGTON · PI MITCHELL, PATRICK S · 2021 to 2025
$2.5M
NIAID NIH HHS DP2 AI154432NIAID NIH HHS P01 AI063302NIAID NIH HHS R37 AI075039NIGMS NIH HHS R35 GM133633NIGMS NIH HHS T32 GM007240NIGMS NIH HHS T32 GM007270NIGMS NIH HHS T32 GM133351NIGMS NIH HHS T32 GM136534
6 · The paper itself

Abstract

Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CL

Identifiers

PMID36172130
PMCPMC9516851
OpenAlexW4296908219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.