Evidence map›Paper›PMID 36172119›Full record

ArticlebioRxiv : the preprint server for biology2022

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques.

Christine E Nelson, Taylor W Foreman, Keith D Kauffman, Shunsuke Sakai, Sydnee T Gould, Joel D Fleegle, Felipe Gomez, NIAID/DIR Tuberculosis Imaging Program, Cyril Le Nouën, Xueqiao Liu and 13 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Christine E NelsonORCID 0000-0003-3879-9105
Taylor W Foreman
Keith D Kauffman
Shunsuke Sakai
Sydnee T Gould
Joel D Fleegle
Felipe Gomez
NIAID/DIR Tuberculosis Imaging Program
Cyril Le Nouën
Xueqiao Liu
Tracey L Burdette
Nicole L Garza
Bernard A P Lafont
Kelsie Brooks
Cecilia S Lindestam ArlehamnORCID 0000-0001-7302-8002
Daniela Weiskopf
Alessandro Sette
Heather D Hickman
Ursula J Buchholz
Reed F Johnson
Jason M Brenchley
Laura E Via
Daniel L Barber

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pro- and anti-inflammatory pathways that determine the balance of inflammation and viral control during SARS-CoV-2 infection are not well understood. Here we examine the roles of IFNγ and IL-10 in regulating inflammation, immune cell responses and viral replication during SARS-CoV-2 infection of rhesus macaques. IFNγ blockade tended to decrease lung inflammation based on

Identifiers

PMID36172119
PMCPMC9516850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.