Evidence map›Paper›PMID 36172030›Full record

ArticleFrontiers in neurology2022

Baseline blood pressure does not modify the effect of intravenous thrombolysis in successfully revascularized patients.

Zhang Xiaoxi, Zhu Xuan, Zhang Lei, Li Zifu, Xing Pengfei, Shen Hongjian, Zhang Yongxin, Hua Weilong, Zhou Yihan, Dai Dongwei and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03469206 (Parallel Group, Randomized Clinical Trial of Direct Intra-arterial Thrombectomy Versus Intravenous Thrombolysis With Intra-arterial Thrombectomy for Patients With Large Vessel Occlusion of the Anterior Circulation), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03469206 nacompletednot on this map

Parallel Group, Randomized Clinical Trial of Direct Intra-arterial Thrombectomy Versus Intravenous Thrombolysis With Intra-arterial Thrombectomy for Patients With Large Vessel Occlusion of the Anterior Circulation

TypeinterventionalSponsorChanghai HospitalRan2018 to 2019Enrolled656ConditionsIschemic Stroke, Large Vessel Occlusion, Thrombectomy, ThrombosisArmsintra-arterial thrombectomy, Intravenous thrombolysis
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Zhang XiaoxiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhu XuanNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhang LeiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Li ZifuNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Xing PengfeiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Shen HongjianNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhang YongxinNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Hua WeilongNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhou YihanNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Dai DongweiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Li QiangNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhao RuiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Huang QinghaiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Xu YiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Lili SongGlobal Brain Health, The George Institute for Global Health, Beijing, China.
Craig S AndersonThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Liu JianminNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhang YongweiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yang PengfeiNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Second Military Medical University · CNChanghai Hospital · CNThe George Institute for Global Health · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies indicate a trajectory relationship between baseline blood pressure (BP) and outcome in patients with acute ischemic stroke (AIS) eligible for both intravenous thrombolysis (IVT) with alteplase and endovascular treatment (EVT). We determined whether baseline BP modified the effect of IVT in successfully revascularized AIS patients who participated in the Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals (DIECT-MT) trial. Methods: The association of baseline systolic BP, trichotomized as high (141-185 mmHg), middle (121-140 mmHg), and low (91-120 mmHg), and the outcomes of any intracerebral hemorrhage (ICH), symptomatic ICH (sICH), and mortality and functional outcome on the modified Rankin scale at 90 days were explored. Logistic regression models determined the interaction between clinical outcomes and baseline systolic and diastolic BP, and mean arterial pressure (MAP), at 10 mmHg intervals. Data are reported as odds ratios (OR) and 95% CI. Results: A Conclusions: In patients with baseline SBP under 185 mmHg, baseline blood pressure does not alter the risk of hemorrhagic transformation and clinicaloutcome in successfully revascularized patients, regardless of intravenous alteplase usage. Future studies are needed to confirm our findings. Registration: URL: http://www.clinicaltrials.gov, Identifier: NCT03469206.

Indexed as

acute ischemic strokebaseline blood pressureendovascular thrombectomyendovascular treatmentintravenous thrombolysis

Identifiers

PMID36172030
PMCPMC9510834
OpenAlexW4295328847

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.