Evidence map›Paper›PMID 36171625›Full record

ArticleMicrobiome2022

Selected commensals educate the intestinal vascular and immune system for immunocompetence.

Rossana Romero, Agnieszka Zarzycka, Mathieu Preussner, Florence Fischer, Torsten Hain, Jan-Paul Herrmann, Katrin Roth, Corinna U Keber, Kushal Suryamohan, Hartmann Raifer and 10 more

Abstract readVideo-Audio Media
In one paragraph

Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. The OMMGut microbes · 2026
    Review
  2. Article
  3. International journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. The gut microbiome as a modulator of arterial function and age-related arterial dysfunction.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  14. Gut Microbiota and the Microvasculature.Cold Spring Harbor perspectives in medicine · 2023
    Review
  15. Review
  16. Article
  17. Gut microbes
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rossana RomeroInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Agnieszka ZarzyckaInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Mathieu PreussnerInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Florence FischerInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Torsten HainInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, Germany.
Jan-Paul HerrmannInstitute of Medical Microbiology, Justus Liebig University Giessen, Giessen, Germany.
Katrin RothCenter for Tumor Biology and Immunology, Philipps University Marburg, Marburg, Germany.
Corinna U KeberPathology, University Hospital of Giessen and Marburg (UKGM), Marburg, Germany.
Kushal SuryamohanMedgenome, Inc., San Mateo, CA, USA.
Hartmann RaiferFlow Cytometry Core Facility, Philipps University Marburg, Marburg, Germany.
Maik LuuInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Hanna LeisterInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Wilhelm BertramsInstitute for Lung Research, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, Marburg, Germany.
Matthias KleinInstitute for Immunology, University Medical Center Johannes Gutenberg University, Mainz, Germany.
Hosam Shams-EldinTierexperimentelle Einrichtung, Philipps University of Marburg, Marburg, Germany.
Ralf JacobDepartment of Cell Biology and Cell Pathology, Philipps University of Marburg, Marburg, Germany.
Hans-Joachim MollenkopfDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
Krishnaraj RajalingamCell Biology Unit, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Alexander VisekrunaInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Ulrich SteinhoffInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany. ulrich.steinhoff@staff.uni-marburg.de.ORCID 0000-0003-2141-7756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe intestinal microbiota fundamentally guides the development of a normal intestinal physiology, the education, and functioning of the mucosal immune system. The Citrobacter rodentium-carrier model in germ-free (GF) mice is suitable to study the influence of selected microbes on an otherwise blunted immune response in the absence of intestinal commensals.

resultsHere, we describe that colonization of adult carrier mice with 14 selected commensal microbes (OMM

conclusionsConsortium modeling revealed that the addition of two facultative anaerobes to the OMM

Indexed as

Citrobacter rodentiumIntestinal MucosaAnimalsImmune SystemImmunocompetenceIntestinesMiceAsymptomatic infectionBlood vessel developmentColonization resistanceCommensal imprintingC. rodentiumEndothelial cellsEnteric pathogenGenome-guided microbiotaIntestinal maturationMicrobial consortiaNeutrophilsOligo-Mouse-Microbiota

Identifiers

PMID36171625
PMCPMC9520927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.