Evidence map›Paper›PMID 36171541›Full record

ArticleClinical proteomics2022

The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo and 55 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical proteomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

65 authors at 11 institutions in 5 countries.

Guillaume Butler-LaporteLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Edgar Gonzalez-KozlovaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chen-Yang SuLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Sirui ZhouLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Tomoko NakanishiLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Elsa Brunet-RatnasinghamResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.
David MorrisonLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Laetitia LaurentLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Jonathan AfilaloLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Marc AfilaloDepartment of Emergency Medicine, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Danielle HenryLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Yiheng ChenLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Julia Carrasco-ZaniniMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Yossi FarjounLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Maik PietznerMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Nofar KimchiLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Zaman AfrasiabiLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Nardin RezkLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Meriem BouabLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Louis PetitjeanLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Charlotte GuzmanLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Xiaoqing XueLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Chris TseliosLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Branka VulesevicLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Olumide AdeleyeLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Tala AbdullahLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Noor AlmamloukLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Yara MoussaLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Chantal DeLucaLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Naomi DugganLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Erwin SchurrInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Nathalie BrassardResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.
Madeleine DurandResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.
Diane Marie Del VallePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ryan ThompsonGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mario A CedilloDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric SchadtGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kai NieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicole W SimonsGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Konstantinos MouskasGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicolas ZakiHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manishkumar PatelPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hui XieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jocelyn HarrisHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert MarvinHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esther ChengGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kevin TuballesPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kimberly ArguetaHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ieisha ScottHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai COVID-19 Biobank Team
Celia M T GreenwoodLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Clare PatersonSomaLogic Inc, Boulder, CO, USA.
Michael HinterbergSomaLogic Inc, Boulder, CO, USA.
Claudia LangenbergMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Vincenzo ForgettaLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Vincent MooserDepartment of Human Genetics, McGill University, Montréal, Québec, Canada.
Thomas MarronDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Noam BeckmannGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ephraim KenigsbergGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander W CharneyMount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seunghee Kim-SchulzeHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miriam MeradPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel E KaufmannResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.
Sacha GnjaticHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Brent RichardsLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada. brent.richards@mcgill.ca.ORCID http://orcid.org/0000-0002-3746-9086
Icahn School of Medicine at Mount Sinai · USJewish General Hospital · CAMcGill University · CACentre Hospitalier de l’Université de Montréal · CAMount Sinai Hospital · USUniversité de Montréal · CAUniversity of Cambridge · GBSomaLogic (United States) · USJapan Society for the Promotion of Science · JPKing's College London · GBMcGill University Health Centre · CA

Funding

High-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sacha Gnjatic, Seunghee Kim-Schulze · 2017 to 2026
$21.5M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Medical Research Council MC_UU_00006/1NCI NIH HHS U24 CA224319NIH HHS S10 OD026880NIH HHS S10 OD030463
6 · The paper itself

Abstract

introductionSevere COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVID-19 outcomes and underlie differences in outcomes between sexes. Here, we measured 147 immune-related proteins during acute COVID-19 to investigate these questions.

methodsWe measured circulating protein abundances using the SOMAscan nucleic acid aptamer panel in two large independent hospital-based COVID-19 cohorts in Canada and the United States. We fit generalized additive models with cubic splines from the start of symptom onset to identify protein levels over the first 14 days of infection which were different between severe cases and controls, adjusting for age and sex. Severe cases were defined as individuals with COVID-19 requiring invasive or non-invasive mechanical respiratory support.

results580 individuals were included in the analysis. Mean subject age was 64.3 (sd 18.1), and 47% were male. Of the 147 proteins, 69 showed a significant difference between cases and controls (p < 3.4 × 10

conclusionsSevere COVID-19 is associated with large changes in 69 immune-related proteins. Further, five proteins were associated with sex differences in outcomes. These results provide direct insights into immune-related proteins that are strongly influenced by severe COVID-19 infection.

Indexed as

COVID-19ImmunityProteomicsSOMAscan

Identifiers

PMID36171541
PMCPMC9516500
OpenAlexW4297491644

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.