Evidence map›Paper›PMID 36171518›Full record

ArticleNeurocritical care2023

Temporal Patterns in Brain Tissue and Systemic Oxygenation Associated with Mortality After Severe Traumatic Brain Injury in Children.

Jaskaran Rakkar, Justin Azar, Jonathan H Pelletier, Alicia K Au, Michael J Bell, Dennis W Simon, Patrick M Kochanek, Robert S B Clark, Christopher M Horvat

Open access · greenAbstract read
In one paragraph

Article in Neurocritical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Association between blood pressure augmentation and brain tissue oxygenation in severe pediatric traumatic brain injury: preliminary findings.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  2. Review
  3. An update on pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jaskaran Rakkar *Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Justin Azar *Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jonathan H PelletierDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alicia K AuDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael J BellDivision of Critical Care Medicine, Children's National Hospital, Washington, DC, USA.
Dennis W SimonDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Patrick M KochanekDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Robert S B ClarkDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christopher M HorvatDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. christopher.horvat@chp.edu.ORCID 0000-0002-1593-2252
University of Pittsburgh · USChildren's National · USGeisinger Medical Center · US

Funding

PEDIATRIC NEUROINTENSIVE CARE AND RESUSCITATION RESEARCHT32HD040686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert S B Clark, PATRICK M KOCHANEK · 2000 to 2026
$7.1M
A Learning Health System Approach to Precision Sedation and Analgesia in Critically-Ill ChildrenK23HD099331 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HORVAT, CHRISTOPHER MICHAEL · 2020 to 2024
$810k
NICHD NIH HHS K23 HD099331NICHD NIH HHS L40 HD099798NICHD NIH HHS T32 HD040686
6 · The paper itself

Abstract

backgroundBrain tissue hypoxia is an independent risk factor for unfavorable outcomes in traumatic brain injury (TBI); however, systemic hyperoxemia encountered in the prevention and/or response to brain tissue hypoxia may also impact risk of mortality. We aimed to identify temporal patterns of partial pressure of oxygen in brain tissue (PbtO

methodsData were extracted from the electronic medical record of a quaternary care children's hospital with a level I trauma center for patients ≤ 18 years old with severe TBI and the presence of PbtO

resultsA total of 138 intracranial pressure-monitored patients with TBI (median 5.0 [1.9-12.8] years; 65% boys; admission Glasgow Coma Scale score 4 [3-7]; mortality 18%), 71 with PbtO

conclusionsLower PbtO

Indexed as

Brain InjuriesBrain Injuries, TraumaticHypoxia, BrainAdolescentBrainChildFemaleHumansHypoxiaIntracranial PressureMaleOxygenOxygenBrain tissue oxygenationMortalityPediatricsSystemic oxygenationTraumatic brain injury

Identifiers

PMID36171518
PMCPMC9957965
OpenAlexW4297518387

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.