Evidence map›Paper›PMID 36171451›Full record

ArticleSurgical endoscopy2022

Surgomics: personalized prediction of morbidity, mortality and long-term outcome in surgery using machine learning on multimodal data.

Martin Wagner, Johanna M Brandenburg, Sebastian Bodenstedt, André Schulze, Alexander C Jenke, Antonia Stern, Marie T J Daum, Lars Mündermann, Fiona R Kolbinger, Nithya Bhasker and 14 more

Abstract read
In one paragraph

Article in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  7. Towards multimodal graph neural networks for surgical instrument anticipation.International journal of computer assisted radiology and surgery · 2024
    Article
  8. Article
  9. Parameter-efficient framework for surgical action triplet recognition.International journal of computer assisted radiology and surgery · 2024
    Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Martin WagnerDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany. martin.wagner@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-9831-9110
Johanna M BrandenburgDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
Sebastian BodenstedtDepartment of Translational Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
André SchulzeDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
Alexander C JenkeDepartment of Translational Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
Antonia SternCorporate Research and Technology, Karl Storz SE & Co KG, Tuttlingen, Germany.
Marie T J DaumDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
Lars MündermannCorporate Research and Technology, Karl Storz SE & Co KG, Tuttlingen, Germany.
Fiona R KolbingerDepartment of Visceral-, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Nithya BhaskerDepartment of Translational Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
Gerd SchneiderInstitute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.
Grit Krause-JüttlerDepartment of Visceral-, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Hisham AlwanniCorporate Research and Technology, Karl Storz SE & Co KG, Tuttlingen, Germany.
Fleur Fritz-KebedeInstitute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.
Oliver BurgertResearch Group Computer Assisted Medicine (CaMed), Reutlingen University, Reutlingen, Germany.
Dirk WilhelmDepartment of Surgery, Faculty of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Johannes FallertCorporate Research and Technology, Karl Storz SE & Co KG, Tuttlingen, Germany.
Felix NickelDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
Lena Maier-HeinDepartment of Intelligent Medical Systems (IMSY), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Martin DugasInstitute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.
Marius DistlerDepartment of Visceral-, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jürgen WeitzDepartment of Visceral-, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Beat-Peter Müller-StichDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
Stefanie SpeidelDepartment of Translational Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersonalized medicine requires the integration and analysis of vast amounts of patient data to realize individualized care. With Surgomics, we aim to facilitate personalized therapy recommendations in surgery by integration of intraoperative surgical data and their analysis with machine learning methods to leverage the potential of this data in analogy to Radiomics and Genomics.

methodsWe defined Surgomics as the entirety of surgomic features that are process characteristics of a surgical procedure automatically derived from multimodal intraoperative data to quantify processes in the operating room. In a multidisciplinary team we discussed potential data sources like endoscopic videos, vital sign monitoring, medical devices and instruments and respective surgomic features. Subsequently, an online questionnaire was sent to experts from surgery and (computer) science at multiple centers for rating the features' clinical relevance and technical feasibility.

resultsIn total, 52 surgomic features were identified and assigned to eight feature categories. Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was "surgical skill and quality of performance" for morbidity and mortality (9.0 ± 1.3 on a numerical rating scale from 1 to 10) as well as for long-term (oncological) outcome (8.2 ± 1.8). The feature category with the highest feasibility to be automatically extracted as rated by (computer) scientists was "Instrument" (8.5 ± 1.7). Among the surgomic features ranked as most relevant in their respective category were "intraoperative adverse events", "action performed with instruments", "vital sign monitoring", and "difficulty of surgery".

conclusionSurgomics is a promising concept for the analysis of intraoperative data. Surgomics may be used together with preoperative features from clinical data and Radiomics to predict postoperative morbidity, mortality and long-term outcome, as well as to provide tailored feedback for surgeons.

Indexed as

Machine LearningSurgeonsHumansMorbidityArtificial intelligenceMinimally invasive surgeryPrecision medicinePrediction modelRadiomicsSurgical data science

Identifiers

PMID36171451
PMCPMC9613751

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.