ArticleNature neuroscience2022
Thalamus-driven functional populations in frontal cortex support decision-making.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
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- Constructing mesoscale functionomics by neural dynamics subspace clustering.National science review · 2026Article
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults.Communications medicine · 2026Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- Complementary cortical and thalamic contributions to cell type-specific striatal activity dynamics during movement.Science advances · 2026Article
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Reusable modular architecture enables flexible cognitive operations.Research square · 2025Article
- Decoding decision-making behavior from sparse neural spiking activity.PLoS computational biology · 2025Article
- Interactions Between Depression, Autonomic Dysfunction, Inhibitory Control and Reaction Time: Insights From Heart Rate Variability During Continuous Performance Test.Psychiatry investigation · 2025Article
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
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- A scalable, all-optical method for mapping synaptic connectivity with cell-type specificity.bioRxiv : the preprint server for biology · 2025Article
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- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
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4 authors.
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Abstract
Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and cognitive variables during decision-making. The neural circuit basis for this complex selectivity remains unclear. We examined activity mediating a tactile decision in mouse anterior lateral motor cortex in relation to the underlying circuits. Contrary to the notion of randomly mixed selectivity, an analysis of 20,000 neurons revealed organized activity coding behavior. Individual neurons exhibited prototypical response profiles that were repeatable across mice. Stimulus, choice and action were coded nonrandomly by distinct neuronal populations that could be delineated by their response profiles. We related distinct selectivity to long-range inputs from somatosensory cortex, contralateral anterior lateral motor cortex and thalamus. Each input connects to all functional populations but with differing strength. Task selectivity was more strongly dependent on thalamic inputs than cortico-cortical inputs. Our results suggest that the thalamus drives subnetworks within frontal cortex coding distinct features of decision-making.
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