ArticleScientific reports2022
Live imaging of delamination in Drosophila shows epithelial cell motility and invasiveness are independently regulated.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Phase-field modeling of border cell cluster migration in Drosophila.PLoS computational biology · 2026Article
- ATGL-mediated lipid droplet lipolysis promotes collective migration in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Single-cell transcriptomics reveals stepwise transformation of epithelial cells into Non-Professional Phagocytes.PLoS genetics · 2025Article
- Bellymount-pulsed tracking: a novel approach for real-time in vivo imaging of Drosophila abdominal tissues.G3 (Bethesda, Md.) · 2025Article
- Bellymount-Pulsed Tracking: A Novel Approach for Real-Time In vivo Imaging ofbioRxiv : the preprint server for biology · 2024Article
- JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development.Nature communications · 2024Article
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Abstract
Delaminating cells undergo complex, precisely regulated changes in cell-cell adhesion, motility, polarity, invasiveness, and other cellular properties. Delamination occurs during development and in pathogenic conditions such as cancer metastasis. We analyzed the requirements for epithelial delamination in Drosophila ovary border cells, which detach from the structured epithelial layer and begin to migrate collectively. We used live imaging to examine cellular dynamics, particularly epithelial cells' acquisition of motility and invasiveness, in delamination-defective mutants during the time period in which delamination occurs in the wild-type ovary. We found that border cells in slow border cells (slbo), a delamination-defective mutant, lacked invasive cellular protrusions but acquired basic cellular motility, while JAK/STAT-inhibited border cells lost both invasiveness and motility. Our results indicate that invasiveness and motility, which are cooperatively required for delamination, are regulated independently. Our reconstruction experiments also showed that motility is not a prerequisite for acquiring invasiveness.
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