ArticleNature2022
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 31 citations in OpenAlex.
- Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.eLife · 2026Article
- Dual-line Genome-scale CRISPR Screening Enables Robust Target Gene Discovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening.Biochemical Society transactions · 2026Review
- Annotating genomes at increased scale and resolution.Nature reviews. Genetics · 2026Review
- Genome-wide CRISPR knockout cell screening platform for the disease vector tick speciesbioRxiv : the preprint server for biology · 2026Article
- Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.Nature microbiology · 2026Article
- Discovery of a fungal Tc toxin complex and functional mycoserpin through a novel two-by-two comparative genomics approach.Frontiers in cellular and infection microbiology · 2026Article
- Approaches to deorphanize secretome: Classical, computational, and next generation strategies to reveal ligand-receptor networks.EXO : beyond the cell · 2026Article
- Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins.Nature communications · 2025Article
- A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes.Nature communications · 2025Article
- Injection of Affibodies by a Self-Organizing Bacterial Syringe to Interfere with Intracellular Signaling.Toxins · 2025Article
- Characterization of toxin systems of Paenibacillus strains isolated from honeybees.Scientific reports · 2025Article
- Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC).Nature communications · 2025Article
- CRISPR/Cas9-Mediated Knockout of theInsects · 2025Article
- Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins.Nature protocols · 2025Review
- Multistate kinetics of the syringe-like injection mechanism of Tc toxins.Science advances · 2025Article
- Review
- Integrating genome-wide CRISPR screens and in silico drug profiling for targeted antidote development.Nature protocols · 2024Review
- Engineered targeting OIP5 sensitizes bladder cancer to chemotherapy resistance via TRIP12-PPP1CB-YBX1 axis.Oncogene · 2024Article
- Some Examples of Bacterial Toxins as Tools.Toxins · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Ying Xu *Department of Urology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8888-786X
Raghuvir Viswanatha *Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Oleg SitselDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID http://orcid.org/0000-0002-4496-7489
Daniel RodererDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID http://orcid.org/0000-0002-7276-3467
Haifang ZhaoJiangsu Key Laboratory of Biological Cancer, Cancer Institute, Xuzhou Medical University, Xuzhou, China.
Christopher AshwoodDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Cecilia VoelckerBeth Israel Deaconess Medical Center Glycomics Core, Boston, MA, USA.
Songhai TianDepartment of Urology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6630-1904
Stefan RaunserDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany. stefan.raunser@mpi-dortmund.mpg.de.ORCID http://orcid.org/0000-0001-9373-3016
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0001-7542-472X
Min DongDepartment of Urology, Boston Children's Hospital, Boston, MA, USA. min.dong@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-1744-7293
Boston Children's Hospital · USBeth Israel Deaconess Medical Center · USHoward Hughes Medical Institute · USMax Planck Institute of Molecular Physiology · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DEXuzhou Medical College · CN
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MStructure and Function of C. Difficile ToxinsR01AI139087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Min Dong, Rongsheng Jin · 2018 to 2026
$7.4MFunctional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2019 to 2023
$6.8MLong-term effects of botulinum neurotoxins on neuronal viabilityR01NS080833 · NINDS · HARVARD MEDICAL SCHOOL · PI Min Dong · 2013 to 2026
$6.8MGenome-wide CRISPR-Cas9 screens in insect cells to characterize insecticidal toxinsR01AI170835 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN, PERRIMON, NORBERT · 2022 to 2025
$4.2MMolecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2017 to 2021
$3.5MTargeted Delivery of Therapeutics into Motor Neurons for Post-exposure Treatment of BotulismR01NS117626 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2021 to 2025
$3.3MHoward Hughes Medical InstituteNIAID NIH HHS R01 AI132387NIAID NIH HHS R01 AI139087NIAID NIH HHS R01 AI170835NICHD NIH HHS P30 HD018655NIDDK NIH HHS P30 DK034854NIGMS NIH HHS P41 GM132087NINDS NIH HHS R01 NS080833NINDS NIH HHS R01 NS117626
Abstract
Entomopathogenic nematodes are widely used as biopesticides
Indexed as
Bacterial ToxinsCRISPR-Cas SystemsDrosophila melanogasterDrosophila ProteinsGene EditingVirulence FactorsAnimalsBiological Control AgentsCulicidaeFat BodyGene Knockdown TechniquesHemocytesHumansMothsMucinsPest Control, BiologicalBacterial ToxinsBiological Control AgentsDrosophila ProteinsMucinsVirulence Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.