ArticleNature2022
Bespoke library docking for 5-HT
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.
0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
44.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed, 242 citations in OpenAlex.
- Sustained antidepressant-like effects of psychedelics through 5-HTNature neuroscience · 2026Article
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Mechanistic Basis for 5-HTNature communications · 2026Article
- Structure-based design of subtype-selective psychedelic analogs.Nature communications · 2026Article
- Structure based discovery of antipsychotic-like TAAR1 agonists.Nature communications · 2026Article
- Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs.ACS chemical neuroscience · 2026Article
- Modeling the Sensitivity of Large-Scale Virtual Screening to Scoring Function Accuracy, Artifacts, and Library Composition.Journal of chemical information and modeling · 2026Article
- Library Docking for Cannabinoid-2 Receptor Ligands.Journal of medicinal chemistry · 2026Article
- Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.Nature communications · 2026Article
- 5-HTZoological research · 2026Article
- Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin.bioRxiv : the preprint server for biology · 2026Article
- The working lives of neuronal 5-HTRSC chemical biology · 2026Review
- V-SYNTHES2-the next generation tool for structure-based virtual screening of giga-scale chemical spaces.npj drug discovery · 2026Article
- Preclinical models for evaluating psychedelics in the treatment of major depressive disorder.British journal of pharmacology · 2026Review
- FlowDock: A unified flow-based framework for flexible protein-ligand docking and binding affinity prediction.Acta pharmaceutica Sinica. B · 2026Article
- Mechanistic insights toward dissociating therapeutic from psychedelic effects: bridging the gap between psychedelic research and mental health care.Translational psychiatry · 2026Review
- Serotonin Transporter Blockade Reduces the Psychedelic-Like Effects of 4-Methoxy-ACS chemical neuroscience · 2026Article
- A structural overview of G-protein-coupled receptors in neurological disorders.Acta pharmacologica Sinica · 2026Review
- Open-Source Molecular Docking and AI-Augmented Structure-Based Drug Design: Current Workflows, Challenges, and Opportunities.International journal of molecular sciences · 2026Review
- Library docking for Cannabinoid-2 Receptor ligands.bioRxiv : the preprint server for biology · 2026Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 11 institutions in 3 countries.
Anat Levit Kaplan *Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Danielle N Confair *Department of Chemistry, Yale University, New Haven, CT, USA.
Kuglae Kim *Department of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Ximena Barros-Álvarez *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Ramona M RodriguizDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Ying YangDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Oh Sang KweonDepartment of Chemistry, Yale University, New Haven, CT, USA.
Tao CheCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-1620-3027
John D McCorvyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-7555-9413
David N KamberDepartment of Chemistry, Yale University, New Haven, CT, USA.
James P PhelanDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-0058-0653
Luan Carvalho MartinsDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7747-6782
Vladimir M PogorelovDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Jeffrey F DiBertoDepartment of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8227-2071
Samuel T SlocumDepartment of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Xi-Ping HuangNational Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Jain Manish KumarDepartment of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-8173-3326
Michael J RobertsonDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2610-680X
Ouliana PanovaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Alpay B SevenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Autumn Q WetselDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
William C WetselDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. william.wetsel@duke.edu.ORCID http://orcid.org/0000-0002-3592-7397
John J IrwinDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. jji@cgl.ucsf.edu.ORCID http://orcid.org/0000-0002-1195-6417
Georgios SkiniotisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.ORCID http://orcid.org/0000-0003-0238-7846
Brian K ShoichetDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. bshoichet@gmail.com.ORCID http://orcid.org/0000-0002-6098-7367
Bryan L RothDepartment of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA. bryan_roth@med.unc.edu.ORCID http://orcid.org/0000-0002-0561-6520
Jonathan A EllmanDepartment of Chemistry, Yale University, New Haven, CT, USA. jonathan.ellman@yale.edu.ORCID http://orcid.org/0000-0001-9320-5512
University of North Carolina at Chapel Hill · USYale University · USStanford University · USUniversity of California, San Francisco · USDuke Medical Center · USDuke University · USMedical College of Wisconsin · USNational Institute of Mental Health · USStanford Medicine · USUniversidade Federal de Minas Gerais · BRWashington University in St. Louis · US
Funding
Development and Testing of New Computational Methods for Ligand Discovery and MechanismR35GM122481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian K Shoichet · 2017 to 2026
$8.5MNext-generation C-H functionalization methods for organic synthesis and their applications to biological inquiryR35GM122473 · NIGMS · YALE UNIVERSITY · PI JONATHAN A ELLMAN · 2017 to 2026
$7.6MMolecular Details of Psychoactive Drug ActionsR01MH112205 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2017 to 2026
$6.1MA Web-Based Automatic Virtual Screening SystemR01GM071896 · NIGMS · UNIVERSITY OF TORONTO · PI IRWIN, JOHN J. · 2004 to 2024
$6.0MMechanistic insights into LSD actions at 5-HT2A serotonin receptorsR37DA045657 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth · 2018 to 2026
$5.8MNEURONAL SIGNALING AND NEUROPEPTIDE EXPRESSIONF32MH011205 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI RAJAN, PRITHI · 1995 to 1995
–NIDA NIH HHS R37 DA045657NIGMS NIH HHS R01 GM071896NIGMS NIH HHS R35 GM122473NIGMS NIH HHS R35 GM122481NIMH NIH HHS F32 MH011205NIMH NIH HHS R01 MH112205
Abstract
There is considerable interest in screening ultralarge chemical libraries for ligand discovery, both empirically and computationally
Indexed as
Antidepressive AgentsPyrrolidinesReceptor, Serotonin, 5-HT2AAnimalsCryoelectron MicroscopyFluoxetineHallucinogensLigandsMiceSmall Molecule LibrariesAntidepressive AgentsFluoxetineHallucinogensLigandsPyrrolidinesReceptor, Serotonin, 5-HT2ASmall Molecule Libraries
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.