Evidence map›Paper›PMID 36171287›Full record

ArticleNature2022

LRRC15

Akshay T Krishnamurty, Justin A Shyer, Minh Thai, Vineela Gandham, Matthew B Buechler, Yeqing Angela Yang, Rachana N Pradhan, Amber W Wang, Patricia L Sanchez, Yan Qu and 21 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed
33.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 358 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Key regulatory elements of the TGFβ-LRRC15 axis predict disease progression and immunotherapy resistance across cancer types.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. SDC1Gut · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Review

223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 2 institutions in 2 countries.

Akshay T KrishnamurtyGenentech, South San Francisco, CA, USA.
Justin A ShyerGenentech, South San Francisco, CA, USA.
Minh ThaiGenentech, South San Francisco, CA, USA.
Vineela GandhamGenentech, South San Francisco, CA, USA.
Matthew B BuechlerGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1902-622X
Yeqing Angela YangGenentech, South San Francisco, CA, USA.
Rachana N PradhanGenentech, South San Francisco, CA, USA.
Amber W WangGenentech, South San Francisco, CA, USA.
Patricia L SanchezGenentech, South San Francisco, CA, USA.
Yan QuGenentech, South San Francisco, CA, USA.
Beatrice BreartGenentech, South San Francisco, CA, USA.
Cécile ChalouniGenentech, South San Francisco, CA, USA.
Debra DunlapGenentech, South San Francisco, CA, USA.
James ZiaiGenentech, South San Francisco, CA, USA.
Justin ElstrottGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6694-5929
Neelie ZachariasGenentech, South San Francisco, CA, USA.
Weiguang MaoGenentech, South San Francisco, CA, USA.
Rebecca K RowntreeGenentech, South San Francisco, CA, USA.
Jack SadowskyGenentech, South San Francisco, CA, USA.
Gail D LewisGenentech, South San Francisco, CA, USA.
Thomas H PillowGenentech, South San Francisco, CA, USA.
Barzin Y NabetGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4824-3533
Romain BanchereauGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6916-6445
Lucinda TamGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3101-6684
Roger CaothienGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6286-7767
Natasha BacarroGenentech, South San Francisco, CA, USA.
Merone Roose-GirmaGenentech, South San Francisco, CA, USA.
Zora ModrusanGenentech, South San Francisco, CA, USA.
Sanjeev MariathasanGenentech, South San Francisco, CA, USA.
Sören MüllerGenentech, South San Francisco, CA, USA. Muller.Soren@gene.com.ORCID http://orcid.org/0000-0001-9490-5270
Shannon J TurleyGenentech, South San Francisco, CA, USA. Turley.Shannon@gene.com.ORCID http://orcid.org/0000-0002-0444-3031
Genesys (United States) · USGene Therapy Laboratory · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent single-cell studies of cancer in both mice and humans have identified the emergence of a myofibroblast population specifically marked by the highly restricted leucine-rich-repeat-containing protein 15 (LRRC15)

Indexed as

Cancer-Associated FibroblastsMembrane ProteinsMyofibroblastsPancreatic NeoplasmsStromal CellsAnimalsB7-H1 AntigenCD8-Positive T-LymphocytesHumansMiceReceptors, Transforming Growth Factor betaTransforming Growth Factor betaTumor MicroenvironmentB7-H1 AntigenLrrc15 protein, mouseMembrane ProteinsReceptors, Transforming Growth Factor betaTransforming Growth Factor beta

Identifiers

PMID36171287
PMCPMC9630141
OpenAlexW4297497831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.