ArticleScientific reports2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Efficacy of very early interventions on neurodevelopmental outcomes for infants and toddlers at increased likelihood of or diagnosed with autism: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2023Pooled it
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Functional Connectivity in the Social Perception Pathway at Birth Is Linked to Attention to Faces at Four Months.Biological psychiatry global open science · 2025Article
- Third-Trimester Development of Central Autonomic Network Connectivity Is Altered in an Extrauterine Environment.Neonatology · 2025Article
- Functional structure of local connections and differentiation of cerebral cortex areas in the neonate.NeuroImage · 2024Article
- Atypical functional connectivity between the amygdala and visual, salience regions in infants with genetic liability for autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Salience network connectivity is altered in 6-week-old infants at heightened likelihood for developing autism.Communications biology · 2024Article
- Autism-associated brain differences can be observed in utero using MRI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Structural Brain Imaging Biomarkers of Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring.The American journal of psychiatry · 2023Article
- Associations between thalamocortical functional connectivity and sensory over-responsivity in infants at high likelihood for ASD.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Altered resting state functional connectivity (FC) involving the anterior insula (aINS), a key node in the salience network, has been reported consistently in autism. Here we examined, for the first time, FC between the aINS and the whole brain in a sample of full-term, postmenstrual age (PMA) matched neonates (mean 44.0 weeks, SD = 1.5) who due to family history have high likelihood (HL) for developing autism (n = 12) and in controls (n = 41) without family history of autism (low likelihood, LL). Behaviors associated with autism were evaluated between 12 and 18 months (M = 17.3 months, SD = 2.5) in a subsample (25/53) of participants using the First Year Inventory (FYI). Compared to LL controls, HL neonates showed hypoconnectivity between left aINS and left amygdala. Lower connectivity between the two nodes was associated with higher FYI risk scores in the social domain (r(25) = -0.561, p = .003) and this association remained robust when maternal mental health factors were considered. Considering that a subsample of LL participants (n = 14/41) underwent brain imaging during the fetal period at PMA 31 and 34 weeks, in an exploratory analysis, we evaluated prospectively development of the LaINS-Lamy connectivity and found that the two areas strongly coactivate throughout the third trimester of pregnancy. The study identifies left lateralized anterior insula-amygdala connectivity as a potential target of further investigation into neural circuitry that enhances likelihood of future onset of social behaviors associated with autism during neonatal and potentially prenatal periods.
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