Evidence map›Paper›PMID 36171111›Full record

ArticleThe Journal of veterinary medical science2022

Direct evidence of nitric oxide production induced by lactoferrin and its enhancement by magnesium ions in cultured endothelial cells.

Tomoaki Nii, Md Zahorul Islam, Satoru Kake, Mitsuya Shiraishi, Takashi Takeuchi, Hidefumi Kuwata, Atsushi Miyamoto, Etsumori Harada

Open access · diamondAbstract read
In one paragraph

Article in The Journal of veterinary medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tomoaki NiiDepartment of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Md Zahorul IslamDepartment of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Satoru KakeDepartment of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Mitsuya ShiraishiDepartment of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Takashi TakeuchiDepartment of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan.
Hidefumi KuwataNRL Pharma. Inc., Kanagawa, Japan.
Atsushi MiyamotoDepartment of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Etsumori HaradaTottori University, Tottori, Japan.
Kagoshima University · JPTottori University · JPBangladesh Agricultural University · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine lactoferrin (BLF) reportedly lowers blood pressure and induces vasorelaxation, but its effect on nitric oxide (NO) production has not been established. Accordingly, we aimed to determine whether BLF induces NO production in bovine aortic endothelial cells, and the effects of extracellular free magnesium (Mg) ion concentrations on this NO production. BLF induced NO production time-dependently. NO production was markedly inhibited by the NO synthase inhibitor, N

Indexed as

LactoferrinNitric OxideAnimalsCells, CulturedEndothelial CellsIonsMagnesiumIonsLactoferrinMagnesiumNitric Oxidebovine aorta endothelial cellcell culturelactoferrinmagnesiumnitric oxide production

Identifiers

PMID36171111
PMCPMC9705813
OpenAlexW4297965283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.