ArticleAnnals of the rheumatic diseases2023
Low copy numbers of complement
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Article in Annals of the rheumatic diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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12citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta-Analyses.Arthritis & rheumatology (Hoboken, N.J.) · 2025Pooled it
- Association of HLA-DR, HLA-DQ, and HLA-B alleles with inclusion body myositis risk: A systematic review, a meta-analysis, a meta-regression and a trial sequential analysis.International journal of immunopathology and pharmacologyPooled it
- Juvenile Myositis: Insights on Classification, Pathogenesis, and Therapies Over the Past 50 Years.Arthritis care & research · 2026Review
- Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- HLA loci heterozygosity modulates genetic risk in idiopathic inflammatory myopathies.Annals of the rheumatic diseases · 2025Article
- Article
- Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation.Arthritis research & therapy · 2025Article
- An externally validated clinical-laboratory nomogram for myocardial involvement in adult idiopathic-inflammatory-myopathy patients.Clinical rheumatology · 2024Article
- Dermatomyositis: Practical Guidance and Unmet Needs.ImmunoTargets and therapy · 2024Review
- Serum proteomic analysis uncovers novel serum biomarkers for depression.Frontiers in psychiatry · 2024Article
- Annals of the Rheumatic Diseases collection on autoantibodies in the rheumatic diseases: new insights into pathogenesis and the development of novel biomarkers.Annals of the rheumatic diseases · 2023Review
- The complement system and human autoimmune diseases.Journal of autoimmunity · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 14 institutions in 6 countries.
Danlei ZhouCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0001-9061-1224
Emily H KingCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Simon RothwellNational Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.
Olga KrystufkovaInstitute of Rheumatology and Department of Rheumatology, Charles University, Prague, Czech Republic.
Antonella NotarnicolaDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden.
Samantha CossCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Rabheh Abdul-AzizDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Katherine E MillerCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Amanda DangCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
G Richard YuCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Joanne DrewDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Emeli LundströmDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden.
Lauren M PachmanDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Gulnara MamyrovaDivision of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Rodolfo V CurielDivision of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Boel De PaepeDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Jan L De BleeckerDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Antony PaytonDivision of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
William OllierFaculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.
Terrance P O'HanlonEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, USA.
Ira N TargoffVeteran's Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Willy A FlegelDepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Vidya SivaramanDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Edward OberleDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Shoghik AkoghlanianDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Kyla DriestDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Charles H SpencerUniversity of Mississippi Medical Center, Jackson, Mississippi, USA.
Yee Ling WuDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Haikady N NagarajaDivision of Biostatistics, The Ohio State University, Columbus, Ohio, USA.
Stacy P ArdoinDivision of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Hector ChinoyNational Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-6492-1288
Lisa G RiderEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, USA.
Frederick W MillerEnvironmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2831-9593
Ingrid E LundbergDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6068-9212
Leonid PadyukovDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2950-5670
Jiří VencovskýInstitute of Rheumatology and Department of Rheumatology, Charles University, Prague, Czech Republic.
Janine A LambDivision of Population Health, Health Services Research and Primary Care, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7248-0539
Chack-Yung YuCenter for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA Chack-Yung.Yu@nationwidechildrens.org.ORCID http://orcid.org/0000-0002-5218-7503
for MYOGEN Investigators
Nationwide Children's Hospital · USKarolinska University Hospital · SENational Institutes of Health · USCharles University · CZGeorge Washington University · USGhent University Hospital · BEManchester Academic Health Science Centre · GBUniversity of Manchester · GBCancer Research And Biostatistics · USJackson Memorial Hospital · USManchester Metropolitan University · GBNational Institutes of Health Clinical Center · USNorthwestern University · USVeterans Health Administration · US
Funding
Environmental/genetic Risk Factors and Pathogenesis of Autoimmune DiseaseZIAES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$34.6MComplement in Human Lupus: Deficiencies, Profiles and ComplicationsR01AR073311 · NIAMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BIRMINGHAM, DANIEL J, YU, CHACK Y · 2018 to 2022
$2.1MMHC Complement Variants in Disease Susceptibility of Idiopathic Inflammatory MyopathiesR21AR070509 · NIAMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI YU, CHACK Y · 2017 to 2018
$375kMedical Research Council MR/N003322/1NIAMS NIH HHS R01 AR073311NIAMS NIH HHS R21 AR070509
Abstract
backgroundIdiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle fibres, chronic weakness and fatigue. While complement-mediated destruction of capillary endothelia is implicated in paediatric and adult dermatomyositis, the complex diversity of complement
methodsWe elucidated the gene copy number (GCN) variations of total
resultsThe large study populations helped establish the distribution patterns of various
conclusions
Indexed as
DermatomyositisMyositisAdultAutoantibodiesChildComplement C4Complement C4aDNA Copy Number VariationsGenetic Predisposition to DiseaseHereditary Complement Deficiency DiseasesHLA-DR3 AntigenHLA-DRB1 ChainsHumansRisk FactorsAutoantibodiesComplement C4Complement C4aHLA-DR3 AntigenHLA-DRB1 Chainsautoantibodiesdermatomyositispolymyositis
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.