Evidence map›Paper›PMID 36171057›Full record

ArticleeNeuro

Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry.

Mohammed H Sarikahya, Samantha Cousineau, Marta De Felice, Kendrick Lee, Karen Kw Wong, Marieka V DeVuono, Tony Jung, Mar Rodríguez-Ruiz, Tsun Hay Jason Ng, Dana Gummerson and 5 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Mohammed H SarikahyaAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.ORCID https://orcid.org/0000-0002-5511-2638
Samantha CousineauDepartments of Biochemistry and Chemistry, Western University, London, Ontario N6A 5C1, Canada.
Marta De FeliceAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Kendrick LeeSt. Josephs Health Care, Lawson Health Research Institute, London, Ontario N6C 2R5, Canada.
Karen Kw WongAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Marieka V DeVuonoAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Tony JungAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Mar Rodríguez-RuizAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Tsun Hay Jason NgAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Dana GummersonAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Emma ProudAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Daniel B HardySt. Josephs Health Care, Lawson Health Research Institute, London, Ontario N6C 2R5, Canada.
Ken K-C YeungDepartments of Biochemistry and Chemistry, Western University, London, Ontario N6A 5C1, Canada.
Walter RushlowAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Steven R LavioletteAddiction Research Group, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada steven.laviolette@schulich.uwo.ca.
Western University · CA

Funding

CIHR CRU1126CIHR PJT-159586
6 · The paper itself

Abstract

Despite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. While neurodevelopmental cannabis exposure increases the risk of developing affective/mood disorders in adulthood, the precise neuropathophysiological mechanisms in male and female offspring are largely unknown. Given the interconnectivity of the endocannabinoid (ECb) system and the brain's fatty acid pathways, we hypothesized that prenatal exposure to Δ

Indexed as

CannabinoidsPrenatal Exposure Delayed EffectsAnimalsCannabinoid Receptor AgonistsDronabinolEndocannabinoidsEndophenotypesFatty AcidsFemaleHumansMalePregnancyRatsRats, WistarSignal TransductionCannabinoid Receptor AgonistsCannabinoidsDronabinolEndocannabinoidsFatty AcidselectrophysiologylipidomicsMALDI IMSmesolimbic systemprenatal cannabis exposuresex differences

Identifiers

PMID36171057
PMCPMC9557330
OpenAlexW4297500202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.