ArticleCell reports2022
Motor cortical influence relies on task-specific activity covariation.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Motor Cortical Computations Underlying Natural Dexterous Movement in Freely Flying Bats.bioRxiv : the preprint server for biology · 2026Article
- Selective direct influence of motor cortex on limb muscle activity during naturalistic climbing in mice.Nature neuroscience · 2025Article
- Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.Nature communications · 2025Article
- Motor cortex flexibly deploys a high-dimensional repertoire of subskills.bioRxiv : the preprint server for biology · 2025Article
- Article
- Cortical sculpting of a rhythmic motor program.bioRxiv : the preprint server for biology · 2025Article
- Article
- Corticothalamic neurons in motor cortex have a permissive role in motor execution.Nature communications · 2025Article
- Article
- Increased muscle coactivation is linked with fast feedback control when reaching in unpredictable visual environments.iScience · 2024Article
- Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning.iScience · 2024Article
- Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task.Journal of neurophysiology · 2024Article
- An output-null signature of inertial load in motor cortex.Nature communications · 2024Article
- Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.Cell reports · 2024Article
- Preparatory activity and the expansive null-space.Nature reviews. Neuroscience · 2024Review
- Recording Forelimb Muscle Activity in Head-Fixed Mice with Chronically Implanted EMG Electrodes.Journal of visualized experiments : JoVE · 2024Article
- Identifying Interpretable Latent Factors with Sparse Component Analysis.bioRxiv : the preprint server for biology · 2024Article
- An output-null signature of inertial load in motor cortex.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
5 authors.
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Abstract
During limb movement, spinal circuits facilitate the alternating activation of antagonistic flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints, like when loads are handled. Previous results suggest that these different muscle activation patterns are mediated by separate flexion- and extension-related motor cortical output populations, while others suggest recruitment of task-specific populations. To distinguish between hypotheses, we developed a paradigm in which mice toggle between forelimb tasks requiring antagonist alternation or cocontraction and measured activity in motor cortical layer 5b. Our results conform to neither hypothesis: consistent flexion- and extension-related activity is not observed across tasks, and no task-specific populations are observed. Instead, activity covariation among motor cortical neurons dramatically changes between tasks, thereby altering the relation between neural and muscle activity. This is also observed specifically for corticospinal neurons. Collectively, our findings indicate that motor cortex drives different muscle activation patterns via task-specific activity covariation.
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